15-hydroxy Prostaglandin Dehydrogenase (human recombinant)

15-hydroxy Prostaglandin Dehydrogenase (human recombinant)
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
Cay10007950-100 100 µg -

3 - 10 Werktage*

494,00 €
 
NAD+-dependent 15-hydroxy prostaglandin dehydrogenase (15-PGDH) catalyzes the oxidation of PGs to... mehr
Produktinformationen "15-hydroxy Prostaglandin Dehydrogenase (human recombinant)"
NAD+-dependent 15-hydroxy prostaglandin dehydrogenase (15-PGDH) catalyzes the oxidation of PGs to 15-keto metabolites that have greatly reduced biological activity. Human NAD+-dependent 15-PGDH is a 266 amino acid protein with a molecular weight of 29 kDa and is expressed in multiple tissues including lung, placenta, and kidney. The enzyme belongs to a large family of short-chain alcohol dehydrogenases, which exhibit amino acid identity ranging from 15-30%. Recent studies indicate 15-PGDH may play a role as a tumor suppressor. Studies have shown an inverse correlation between 15-PGDH expression and cell proliferation in colon, breast, and thyroid cells. 15-PGDH specific activity was determined using PGE2 as the substrate and NAD+ as the cofactor and was calculated after subtracting the mass contribution form the GST tag. The reaction was inhibited using CAY10397.
Schlagworte: HPGD, PGDH1, 15-PGDH, EC=1.1.1.141, Prostaglandin dehydrogenase 1, 15-hydroxyprostaglandin dehydrogenase [NAD+]
Hersteller: Cayman Chemical
Hersteller-Nr: 10007950-100

Eigenschaften

Anwendung: Enzyme activity
Konjugat: No
MW: 55 kD
Reinheit: >90% estimated by SDS-PAGE
Format: Solution

Datenbank Information

KEGG ID : K00069 | Finde Alternativen
UniProt ID : P15428 | Finde Alternativen

Handhabung & Sicherheit

Lagerung: -80°C
Versand: -20°C (International: -80°C)
Signalwort: Warning
GHS-Piktogramme:
H-Sätze: H319
P-Sätze: P264, P280, P305+P351+P338, P332+P313, P337+P313
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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