N-(p-Tosyl)-GPR-pNA (acetate)

N-(p-Tosyl)-GPR-pNA is a colorimetric substrate for thrombin. Thrombin preferentially binds to and cleaves the Gly-Pro-Arg (GPR) peptide sequence to release p-nitroanilide (pNA), which can be quantified by colorimetric detection at 405 nm as a measure of thrombin activity.Formal Name: N-[(4-methylphenyl)sulfonyl]glycyl-L-prolyl-N-(4-nitrophenyl)-L-argininamide, monoacetate. CAS Number: 86890-95-1. Synonyms: N-(p-Tosyl)-Gly-Pro-Arg-p-Nitroanilide, Tos-Gly-Pro-Arg-pNA. Molecular Formula: C26H34N8O7S . C2H4O2. Formula Weight: 662.7. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMF: 20 mg/ml, DMSO: 3 mg/ml, PBS (pH 7.2): 3 mg/ml. lambdamax: 225, 314 nm. SMILES: CC1=CC=C(S(NCC(N2CCC[C@H]2C(N[C@@H](CCCNC(N)=N)C(NC3=CC=C([N+]([O-])=O)C=C3)=O)=O)=O)(=O)=O)C=C1.OC(C)=O. InChi Code: InChI=1S/C26H34N8O7S.C2H4O2/c1-17-6-12-20(13-7-17)42(40,41)30-16-23(35)33-15-3-5-22(33)25(37)32-21(4-2-14-29-26(27)28)24(36)31-18-8-10-19(11-9-18)34(38)39,1-2(3)4/h6-13,21-22,30H,2-5,14-16H2,1H3,(H,31,36)(H,32,37)(H4,27,28,29),1H3,(H,3,4)/t21-,22-,/m0./s1. InChi Key: NGXDRWVTRQRSED-VROPFNGYSA-N.