Substrate und Inhibitoren

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YVAD-CHO (trifluoroacetate salt)
YVAD-CHO (trifluoroacetate salt)

Artikelnummer: Cay27420-1

YVAD-CHO is an inhibitor of caspase-1/interleukin-1beta converting enzyme (ICE) and a non-acetylated form of Ac-YVAD-CHO (Cay-10016). It prevents ICE-like and CPP32-like proteinase activity and inhibits apoptosis induced by ceramide or irinotecan (CPT-11, Cay-14180) in 4B1 cells when used at a concentration of 600...
Schlagworte: H-Tyr-Val-Ala-Asp-CHO, L-tyrosyl-L-valyl-N-[(1S)-2-carboxy-1-formylethyl]-L-alaninamide, trifluoroacetate salt
Anwendung: Caspase-1 inhibitor
MW: 450.5 D
ab 44,00 €
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Ac-AAVALLPAVLLALLAP-VAD-CHO (trifluoroacetate salt)
Ac-AAVALLPAVLLALLAP-VAD-CHO (trifluoroacetate salt)

Artikelnummer: Cay27425-1

Ac-AAVALLPAVLLALLAP-VAD-CHO is a composite of Ac-VAD-CHO, a non-selective caspase inhibitor, and a cell-permeable hydrophobic sequence derived from K-FGF. It is a non-selective caspase inhibitor.
Schlagworte: Ac-AAVALLPAVLLALLAP-VAD-aldehyde, Ac-AAVALLPAVLLALLAPVAD-CHO, Caspase Inhibitor II,...
Anwendung: Cell-permeable non-selective caspase inhibitor
MW: 1827.3 D
ab 144,00 €
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Ac-VEID-CHO (trifluoroacetate salt)
Ac-VEID-CHO (trifluoroacetate salt)

Artikelnummer: Cay27437-5

Ac-VEID-CHO is an inhibitor of caspase-6 (IC50 = 16.2 nM). It is selective for caspase-6 over caspase-7 (IC50 = 162.1 nM) but can also inhibit caspase-3 (IC50 = 13.6 nM). Ac-VEID-CHO (100 µM) inhibits ricin-induced caspase-6-, but not caspase-3-, like activity in U937 cells. It also inhibits caspase-6-like activity...
Schlagworte: Ac-Val-Glu-Ile-Asp-CHO,...
Anwendung: Caspase-6 inhibitor
MW: 500.5 D
157,00 €
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Z-YVAD-CMK (trifluoroacetate salt)
Z-YVAD-CMK (trifluoroacetate salt)

Artikelnummer: Cay27435-1

Z-YVAD-CMK is an inhibitor of caspase-1 and caspase-3. It reduces IL-1beta and IL-18 secretion in isolated mouse peritoneal macrophages stimulated by cholesterol-treated recombinant pneumolysin protein (rPLY) when used at a concentration of 30 µM. Z-YVAD-CMK reduces caspase-3 activation by the EGF-like domain of...
Schlagworte: Benxyloxycarbonyl-Tyr-Val-Ala-Asp-Chloromethylketone, Caspase-1 Inhibitor IV,...
Anwendung: Caspase-1 / caspase-3 inhibitor
MW: 633.1 D
ab 62,00 €
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