Selank (acetate)

Selank is a synthetic derivative of the tetrapeptide tuftsin that contains a proline-glycine-proline sequence at the C-terminus and has anxiolytic and anti-inflammatory activities. It increases the amplitude and discharge rate of inhibitory postsynaptic currents of neurons in the rat hippocampal CA1 region when used at a concentration of 1 µM. It decreases the level of affective responses and the number of erroneous escape attempts in rats in an acute stress situation, increases orientational-investigative responses of rats in an unfamiliar situation, and reduces the time mice spend immobile in the forced swim test. It increases locomotor activity of high-anxiety Balb/c, but not C57Bl/6, mice in the open field test. Selank (0.01 mg/kg) decreases verticalization induced by apomorphine (Cay-16094) in mice. It also decreases expression of the inflammation-related genes Il2rg and Xcr1 in mouse spleen after 90 minutes when administered at a dose of 100 µg/kg.Formal Name: L-threonyl-L-lysyl-L-prolyl-L-arginyl-L-prolylglycyl-L-proline, monoacetate. CAS Number: 2703745-90-6. Molecular Formula: C33H57N11O9 . C2H4O2. Formula Weight: 811.9. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: PBS (pH 7.2): 10 mg/ml. SMILES: O=C([C@@H]1CCCN1C(CNC([C@@H]2CCCN2C([C@@H](NC([C@@H]3CCCN3C([C@@H](NC([C@H]([C@H](O)C)N)=O)CCCCN)=O)=O)CCCNC(N)=N)=O)=O)=O)O.OC(C)=O. InChi Code: InChI=1S/C33H57N11O9.C2H4O2/c1-19(45)26(35)29(49)41-20(8-2-3-13-34)30(50)44-17-6-11-23(44)28(48)40-21(9-4-14-38-33(36)37)31(51)43-16-5-10-22(43)27(47)39-18-25(46)42-15-7-12-24(42)32(52)53,1-2(3)4/h19-24,26,45H,2-18,34-35H2,1H3,(H,39,47)(H,40,48)(H,41,49)(H,52,53)(H4,36,37,38),1H3,(H,3,4)/t19-,20+,21+,22+,23+,24+,26+,/m1./s1. InChi Key: OLIPZUSDWNRQRQ-BPKVXTLESA-N.