PAR4 (1-6) (human)

PAR4 (1-6) is a peptide agonist of proteinase-activated receptor 4 (PAR4) that corresponds to residues 1-6 of the amino terminal tethered ligand sequence of human PAR4 and residues 48-53 of the full-length sequence. It activates PAR4 and the cleavage site mutant PAR4R47A when used at a concentration of 500 µM. PAR4 (1-6) induces platelet aggregation of isolated washed human platelets when used at a concentration of 1 mM but does not affect clotting time induced by factor VIIa, soluble tissue factor, and collagen in an ex vivo coagulation assay.Formal Name: glycyl-L-tyrosyl-L-prolylglycyl-L-glutaminyl-L-valine. CAS Number: 225779-44-2. Synonyms: GYPGQV. Molecular Formula: C28H41N7O9. Formula Weight: 619.7. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 50 mg/ml, DMSO: 50 mg/ml, Ethanol: 50 mg/ml, PBS (pH 7.2): 10 mg/ml. lambdamax: 225, 279 nm. SMILES: [H]NCC(N[C@H](C(N1CCC[C@H]1C(NCC(N[C@@H](CCC(N)=O)C(N[C@@H](C(C)C)C(O)=O)=O)=O)=O)=O)CC2=CC=C(O)C=C2)=O. InChi Code: InChI=1S/C28H41N7O9/c1-15(2)24(28(43)44)34-25(40)18(9-10-21(30)37)32-23(39)14-31-26(41)20-4-3-11-35(20)27(42)19(33-22(38)13-29)12-16-5-7-17(36)8-6-16/h5-8,15,18-20,24,36H,3-4,9-14,29H2,1-2H3,(H2,30,37)(H,31,41)(H,32,39)(H,33,38)(H,34,40)(H,43,44)/t18-,19-,20-,24-/m0/s1. InChi Key: VTCFYKYDKDAJKZ-XHOYROJHSA-N.