Neuromedin U-23 (rat) (trifluoroacetate salt)

Neuromedin U-23 (rat) (trifluoroacetate salt)
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
Cay34430-500 500 µg -

6 - 10 Werktage*

123,00 €
Cay34430-1 1 mg -

6 - 10 Werktage*

233,00 €
Cay34430-5 5 mg -

6 - 10 Werktage*

735,00 €
 
Neuromedin U-23 (NMU-23) is a neuropeptide involved in diverse biological processes, including... mehr
Produktinformationen "Neuromedin U-23 (rat) (trifluoroacetate salt)"
Neuromedin U-23 (NMU-23) is a neuropeptide involved in diverse biological processes, including smooth muscle contraction, energy homeostasis, and nociception. It is an agonist of neuromedin-U receptor 1 (NMUR1, EC50 = 0.17 nM for the human receptor in a calcium mobilization assay using HEK293 cells) and NMUR2 (EC50 = ~1.4-2 nM for arachidonic acid release in CHO cells expressing the human receptor). NMU-23 (1 µM) induces contractions in isolated rat colon smooth muscle strips. It decreases body weight and food intake and increases core body temperature in mice when administered at a dose of 36 µg/animal. Intrathecal administration of NMU-23 decreases the mechanical pain threshold in the von Frey test in rats.Formal Name: L-tyrosyl-L-lysyl-L-valyl-L-asparaginyl-L-alpha-glutamyl-L-tyrosyl-L-glutaminylglycyl-L-prolyl-L-valyl-L-alanyl-L-prolyl-L-serylglycylglycyl-L-phenylalanyl-L-phenylalanyl-L-leucyl-L-phenylalanyl-L-arginyl-L-prolyl-L-arginyl-L-aspartamide, trifluoroacetate salt. Synonyms: NMU-23. Molecular Formula: C124H180N34O31 . XCF3COOH. Formula Weight: 2643.0. Purity: >98%. Formulation: A solid. Solubility: DMSO: 1 mg/ml, Ethanol: 1 mg/ml, PBS (pH 7.2): 1 mg/ml. SMILES: O=C([C@H]1N(CCC1)C([C@H](C)NC([C@H](C(C)C)NC([C@H]2N(CCC2)C(CNC([C@H](CCC(N)=O)NC([C@@H](NC([C@H](CCC(O)=O)NC([C@H](CC(N)=O)NC([C@H](C(C)C)NC([C@H](CCCCN)NC([C@@H](N)CC3=CC=C(C=C3)O)=O)=O)=O)=O)=O)CC4=CC=C(C=C4)O)=O)=O)=O)=O)=O)=O)N[C@@H](CO)C(NCC(NCC(N[C@@H](CC5=CC=CC=C5)C(N[C@@H](CC6=CC=CC=C6)C(N[C@@H](CC(C)C)C(N[C@@H](CC7=CC=CC=C7)C(N[C@@H](CCCNC(N)=N)C(N8[C@@H](CCC8)C(N[C@@H](CCCNC(N)=N)C(N[C@H](C(N)=O)CC(N)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O.OC(C(F)(F)F)=O. InChi Code: InChI=1S/C124H180N34O31.C2HF3O2/c1-66(2)54-84(110(177)150-86(57-71-26-13-9-14-27-71)113(180)146-82(32-20-50-136-124(133)134)122(189)158-53-23-35-93(158)116(183)145-79(31-19-49-135-123(131)132)107(174)147-83(103(130)170)60-95(128)163)148-114(181)87(58-72-28-15-10-16-29-72)151-111(178)85(56-70-24-11-8-12-25-70)141-98(166)63-137-97(165)62-138-106(173)90(65-159)153-117(184)92-34-22-52-157(92)121(188)69(7)140-119(186)101(67(3)4)155-118(185)91-33-21-51-156(91)99(167)64-139-105(172)80(44-46-94(127)162)143-112(179)88(59-74-38-42-76(161)43-39-74)149-108(175)81(45-47-100(168)169)144-115(182)89(61-96(129)164)152-120(187)102(68(5)6)154-109(176)78(30-17-18-48-125)142-104(171)77(126)55-73-36-40-75(160)41-37-73,3-2(4,5)1(6)7/h8-16,24-29,36-43,66-69,77-93,101-102,159-161H,17-23,30-35,44-65,125-126H2,1-7H3,(H2,127,162)(H2,128,163)(H2,129,164)(H2,130,170)(H,137,165)(H,138,173)(H,139,172)(H,140,186)(H,141,166)(H,142,171)(H,143,179)(H,144,182)(H,145,183)(H,146,180)(H,147,174)(H,148,181)(H,149,175)(H,150,177)(H,151,178)(H,152,187)(H,153,184)(H,154,176)(H,155,185)(H,168,169)(H4,131,132,135)(H4,133,134,136),(H,6,7)/t69-,77-,78-,79-,80-,81-,82-,83-,84-,85-,86-,87-,88-,89-,90-,91-,92-,93-,101-,102-,/m0./s1. InChi Key: HQYODDZWZPEYJH-VYPWSXOSSA-N.
Schlagworte: NMU-23, L-tyrosyl-L-lysyl-L-valyl-L-asparaginyl-L-alpha-glutamyl-L-tyrosyl-L-glutaminylglycyl-L-prolyl-L-valyl-L-alanyl-L-prolyl-L-serylglycylglycyl-L-phenylalanyl-L-phenylalanyl-L-leucyl-L-phenylalanyl-L-arginyl-L-prolyl-L-arginyl-L-aspartamide, trifluor
Hersteller: Cayman Chemical
Hersteller-Nr: 34430

Eigenschaften

Anwendung: Peptide NMUR agonist
Konjugat: No
MW: 2643 D
Formel: C124H180N34O31 . XCF3COOH
Reinheit: >98%
Format: Solid

Handhabung & Sicherheit

Lagerung: -20°C
Versand: +20°C (International: -20°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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