Neurokinin A (trifluoroacetate salt)

Neurokinin A is a peptide agonist of the neurokinin-2 (NK2) receptor. It potentiates electrically-induced contractions of isolated rat vas deferens and increases vasodilation in the rat hind paw. Neurokinin A (0.3-30 nmol/kg, i.v.) induces bronchoconstriction in guinea pigs in a dose-dependent manner (EC50 = 29 nM), an effect which can be reversed by the NK2 receptor antagonist MEN 10,207.Formal Name: L-histidyl-L-lysyl-L-threonyl-L-alpha-aspartyl-L-seryl-L-phenylalanyl-L-valylglycyl-L-leucyl-L-methioninamide, trifluoroacetate salt. Synonyms: Neurokinin alpha, Neuromedin L, Substance K. Molecular Formula: C50H80N14O14S . XCF3COOH. Formula Weight: 1133.3. Purity: >95%. Formulation: (Request formulation change), A lyophilized powder. Solubility: Water: 1 mg/ml. SMILES: O=C(N[C@@H](CCCCN)C(N[C@]([C@H](O)C)([H])C(N[C@H](C(N[C@@H](CO)C(N[C@H](C(N[C@H](C(NCC(N[C@H](C(N[C@H](C(N)=O)CCSC)=O)CC(C)C)=O)=O)C(C)C)=O)CC1=CC=CC=C1)=O)=O)CC(O)=O)=O)=O)[C@@H](N)CC2=CNC=N2.FC(F)(C(O)=O)F. InChi Code: InChI=1S/C50H80N14O14S.C2HF3O2/c1-26(2)18-34(45(73)58-32(42(53)70)15-17-79-6)57-38(67)23-55-49(77)40(27(3)4)63-47(75)35(19-29-12-8-7-9-13-29)60-48(76)37(24-65)62-46(74)36(21-39(68)69)61-50(78)41(28(5)66)64-44(72)33(14-10-11-16-51)59-43(71)31(52)20-30-22-54-25-56-30,3-2(4,5)1(6)7/h7-9,12-13,22,25-28,31-37,40-41,65-66H,10-11,14-21,23-24,51-52H2,1-6H3,(H2,53,70)(H,54,56)(H,55,77)(H,57,67)(H,58,73)(H,59,71)(H,60,76)(H,61,78)(H,62,74)(H,63,75)(H,64,72)(H,68,69),(H,6,7)/t28-,31+,32+,33+,34+,35+,36+,37+,40+,41+,/m1./s1. InChi Key: CPQMHLIZWAQHOV-LEUAYMAXSA-N.