Histone H3K36Me2 (21-44)-GK-biotin (trifluoroacetate salt)

Histone H3K36Me2 (21-44) is a peptide fragment of histone H3 that corresponds to amino acid residues 22-45 of the human histone H3.1 and H3.2 sequences. It is dimethylated at lysine 36 and biotinylated via a C-terminal GK linker. Dimethylation of H3K36 is enriched at coding regions of genes and correlates with the initiation, but not maintenance, of active transcription.Formal Name: L-alanyl-L-threonyl-L-lysyl-L-alanyl-L-alanyl-L-arginyl-L-lysyl-L-seryl-L-alanyl-L-prolyl-L-alanyl-L-threonylglycylglycyl-L-valyl-N6,N6-dimethyl-L-lysyl-L-lysyl-L-prolyl-L-histidyl-L-arginyl-L-tyrosyl-L-arginyl-L-prolylglycylglycyl-L-lysine-biotin, trifluoroacetate salt. Synonyms: ATKAARKSAPATGGV-K(Me2)-KPHRYRPG-GK(Biotin), [Lys(Me2)36]-Histone H3 (21-44)-GK(Biotin), Histone H3 (21-44) (Lys36me2)-biotin. Molecular Formula: C129H218N44O33S . XCF3COOH. Formula Weight: 2945.5. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: Water: 1 mg/ml. SMILES: O=C(O)C(F)(F)F.CN(C)CCCC[C@H](NC([C@@H](NC(CNC(CNC([C@@]([H])(NC([C@H](C)NC([C@@H]1CCCN1C([C@H](C)NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](C)NC([C@H](C)NC([C@@H](NC([C@@]([H])(NC([C@H](C)N)=O)[C@H](O)C)=O)CCCCN)=O)=O)=O)CCCNC(N)=N)=O)CCCCN)=O)CO)=O)=O)=O)=O)[C@H](O)C)=O)=O)=O)C(C)C)=O)C(N[C@H](C(N2CCC[C@H]2C(N[C@@H](CC3=CN=CN3)C(N[C@H](C(N[C@@H](CC4=CC=C(C=C4)O)C(N[C@H](C(N5CCC[C@H]5C(NCC(NCC(N[C@H](C(O)=O)CCCCNC(CCCC[C@@H]6SC[C@@]([H])([C@@]6(N7)[H])NC7=O)=O)=O)=O)=O)=O)CCCNC(N)=N)=O)=O)CCCNC(N)=N)=O)=O)=O)CCCCN)=O. InChi Code: InChI=1S/C129H218N44O33S.C2HF3O2/c1-68(2)100(166-99(182)64-146-97(180)62-148-119(198)101(74(8)175)168-107(186)72(6)152-117(196)92-39-28-55-171(92)122(201)73(7)153-115(194)89(65-174)164-112(191)80(31-15-20-48-131)156-109(188)82(35-24-51-142-126(134)135)155-106(185)71(5)150-105(184)70(4)151-108(187)79(30-14-19-47-130)159-121(200)102(75(9)176)167-104(183)69(3)133)120(199)158-81(32-18-23-54-170(10)11)110(189)160-84(33-16-21-49-132)123(202)173-57-29-40-93(173)118(197)163-88(59-77-60-140-67-149-77)114(193)157-83(36-25-52-143-127(136)137)111(190)162-87(58-76-43-45-78(177)46-44-76)113(192)161-85(37-26-53-144-128(138)139)124(203)172-56-27-38-91(172)116(195)147-61-96(179)145-63-98(181)154-86(125(204)205)34-17-22-50-141-95(178)42-13-12-41-94-103-90(66-207-94)165-129(206)169-103,3-2(4,5)1(6)7/h43-46,60,67-75,79-94,100-103,174-177H,12-42,47-59,61-66,130-133H2,1-11H3,(H,140,149)(H,141,178)(H,145,179)(H,146,180)(H,147,195)(H,148,198)(H,150,184)(H,151,187)(H,152,196)(H,153,194)(H,154,181)(H,155,185)(H,156,188)(H,157,193)(H,158,199)(H,159,200)(H,160,189)(H,161,192)(H,162,190)(H,163,197)(H,164,191)(H,166,182)(H,167,183)(H,168,186)(H,204,205)(H4,134,135,142)(H4,136,137,143)(H4,138,139,144)(H2,165,169,206),(H,6,7)/t69-,70-,71-,72-,73-,74+,75+,79-,80-,81-,82-,83-,84-,85-,86-,87-,88-,89-,90-,91-,92-,93-,94-,100-,101-,102-,103-,/m0./s1. InChi Key: HQWSCKSKOPJCSY-VUDJXMGVSA-N.