Histone H3K27Ac (21-43)-GGK-biotin (trifluoroacetate salt)

Histone H3K27Ac (21-43)-GGK-biotin is a peptide fragment of histone H3 that corresponds to amino acid residues 22-44 of the human histone H3.1 and H3.2 sequences. It is acetylated at lysine 27 and biotinylated via a C-terminal GGK linker. Acetylation of histone H3 at lysine 27 is associated with active gene transcription. H3K27 acetylation and H3K4 monomethylation are enriched near active enhancers and H3K27 acetylation and H3K4 trimethylation together mark transcription start sites of actively transcribed genes.Formal Name: L-alanyl-L-threonyl-L-lysyl-L-alanyl-L-alanyl-L-arginyl-N6-acetyl-L-lysyl-L-seryl-L-alanyl-L-prolyl-L-alanyl-L-threonylglycylglycyl-L-valyl-L-lysyl-L-lysyl-L-prolyl-L-histidyl-L-arginyl-L-tyrosyl-L-arginyl-L-prolylglycylglycyl-L-lysine-biotin, trifluoroacetate salt. Synonyms: ATKAAR-K(Ac)-SAPATGGVKKPHRYRPG-GK(Biotin), [Lys(Ac)27]-Histone H3 (21-43)-GGK(Biotin). Molecular Formula: C129H216N44O34S . XCF3COOH. Formula Weight: 2959.5. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: Water: 1 mg/ml. SMILES: O=C(O)C(F)(F)F.CC(NCCCC[C@@H](C(N[C@@H](CO)C(N[C@H](C(N1CCC[C@H]1C(N[C@H](C(N[C@]([C@@H](C)O)([H])C(NCC(NCC(N[C@@H](C(C)C)C(N[C@@H](CCCCN)C(N[C@@H](CCCCN)C(N2CCC[C@H]2C(N[C@H](C(N[C@@H](CCCNC(N)=N)C(N[C@H](C(N[C@@H](CCCNC(N)=N)C(N3CCC[C@H]3C(NCC(NCC(N[C@@H](CCCCNC(CCCC[C@@H]4SC[C@@](N5)([H])[C@]4([H])NC5=O)=O)C(O)=O)=O)=O)=O)=O)=O)CC6=CC=C(O)C=C6)=O)=O)CC7=CN=CN7)=O)=O)=O)=O)=O)=O)=O)=O)C)=O)=O)C)=O)=O)NC([C@H](CCCNC(N)=N)NC([C@@H](NC([C@@H](NC([C@H](CCCCN)NC([C@@]([C@@H](C)O)([H])NC([C@@H](N[H])C)=O)=O)=O)C)=O)C)=O)=O)=O. InChi Code: InChI=1S/C129H216N44O34S.C2HF3O2/c1-67(2)100(167-99(183)63-147-97(181)61-149-119(199)101(73(8)175)169-107(187)71(6)153-117(197)92-38-27-54-171(92)122(202)72(7)154-115(195)89(64-174)165-112(192)80(31-16-21-49-141-75(10)177)157-109(189)82(34-23-51-143-126(134)135)156-106(186)70(5)151-105(185)69(4)152-108(188)79(29-13-18-46-130)160-121(201)102(74(9)176)168-104(184)68(3)133)120(200)159-81(30-14-19-47-131)110(190)161-84(32-15-20-48-132)123(203)173-56-28-39-93(173)118(198)164-88(58-77-59-140-66-150-77)114(194)158-83(35-24-52-144-127(136)137)111(191)163-87(57-76-42-44-78(178)45-43-76)113(193)162-85(36-25-53-145-128(138)139)124(204)172-55-26-37-91(172)116(196)148-60-96(180)146-62-98(182)155-86(125(205)206)33-17-22-50-142-95(179)41-12-11-40-94-103-90(65-208-94)166-129(207)170-103,3-2(4,5)1(6)7/h42-45,59,66-74,79-94,100-103,174-176,178H,11-41,46-58,60-65,130-133H2,1-10H3,(H,140,150)(H,141,177)(H,142,179)(H,146,180)(H,147,181)(H,148,196)(H,149,199)(H,151,185)(H,152,188)(H,153,197)(H,154,195)(H,155,182)(H,156,186)(H,157,189)(H,158,194)(H,159,200)(H,160,201)(H,161,190)(H,162,193)(H,163,191)(H,164,198)(H,165,192)(H,167,183)(H,168,184)(H,169,187)(H,205,206)(H4,134,135,143)(H4,136,137,144)(H4,138,139,145)(H2,166,170,207),(H,6,7)/t68-,69-,70-,71-,72-,73+,74+,79-,80-,81-,82-,83-,84-,85-,86-,87-,88-,89-,90-,91-,92-,93-,94-,100-,101-,102-,103-,/m0./s1. InChi Key: DVCZDKROIBGCEX-ZPWRLMCQSA-N.