Gly-Phe-beta-naphthylamide

Gly-Phe-beta-naphthylamide
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
Cay14634-50 50 mg -

6 - 10 Werktage*

77,00 €
Cay14634-100 100 mg -

6 - 10 Werktage*

114,00 €
Cay14634-500 500 mg -

6 - 10 Werktage*

514,00 €
 
Cathepsin C is a lysosomal cysteine protease with broad exopeptidase activity that progressively... mehr
Produktinformationen "Gly-Phe-beta-naphthylamide"
Cathepsin C is a lysosomal cysteine protease with broad exopeptidase activity that progressively removes dipeptides from various protein and polypeptides substrates. Aside from its role in post-translational processing, cathepsins may also participate in apoptotic signaling pathways by targeting cytosolic caspases and proapoptotic proteins. Gly-Phe-beta-naphthylamide is a substrate of cathepsin C that accumulates within the lysosome. Hydrolysis by cathepsin C degrades Gly-Phe-beta-naphthylamide into fragments that do not easily diffuse through the lysosomal membrane, leading to a loss of lysosome membrane integrity. This compound has been used to study intralysosomal hydrolysis, lysosomal membrane permeability, and the function of cathepsin C. At 50 µM, Gly-Phe-beta-naphthylamide can inhibit the cathepsin-dependent activation of caspase-8.Formal Name: glycyl-N-2-naphthalenyl-L-phenylalaninamide. CAS Number: 21438-66-4. Synonyms: H-Gly-Phe-BNA. Molecular Formula: C21H21N3O2. Formula Weight: 347.4. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 25 mg/ml, DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml, DMSO: 20 mg/ml, Ethanol: 1 mg/ml. lambdamax: 243, 283 nm. SMILES: NCC(N[C@@H](CC1=CC=CC=C1)C(NC2=CC(C=CC=C3)=C3C=C2)=O)=O. InChi Code: InChI=1S/C21H21N3O2/c22-14-20(25)24-19(12-15-6-2-1-3-7-15)21(26)23-18-11-10-16-8-4-5-9-17(16)13-18/h1-11,13,19H,12,14,22H2,(H,23,26)(H,24,25)/t19-/m0/s1. InChi Key: YABDXPBHLDPMOA-IBGZPJMESA-N.
Schlagworte: H-Gly-Phe-BNA, glycyl-N-2-naphthalenyl-L-phenylalaninamide
Hersteller: Cayman Chemical
Hersteller-Nr: 14634

Eigenschaften

Anwendung: Cathepsin C substrate
Konjugat: No
MW: 347.4 D
Formel: C21H21N3O2
Reinheit: >95%
Format: Crystalline Solid

Datenbank Information

CAS : 21438-66-4| Passende Produkte
KEGG ID : K01275 | Passende Produkte

Handhabung & Sicherheit

Lagerung: -20°C
Versand: +20°C (International: -20°C)
Signalwort: Danger
GHS-Piktogramme:
H-Sätze: H350
P-Sätze: P201, P202, P280, P308+313, P405, P501
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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