beta-Defensin-1 (human) (trifluoroacetate salt)

beta-Defensin-1 (human) (trifluoroacetate salt)
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
Cay24576-100 100 µg -

6 - 10 Werktage*

488,00 €
 
beta-Defensin-1 is a peptide with antimicrobial properties that protects the skin and mucosal... mehr
Produktinformationen "beta-Defensin-1 (human) (trifluoroacetate salt)"
beta-Defensin-1 is a peptide with antimicrobial properties that protects the skin and mucosal membranes of the respiratory, genitourinary, and gastrointestinal tracts. It inhibits the growth of B. adolescentis, L. acidophilus, B. breve, B. vulgatus, L. fermentum, B. longum, and S. thermophilus in an antimicrobial radial diffusion assay. beta-Defensin-1 also inhibits the growth of periodontopathogenic and cariogenic bacteria, including P. gingivalis and S. salivarius, and of susceptible M. tuberculosis H37Rv but not of resistant M. tuberculosis RM22 when used at a concentration of 128 µg/ml. It blocks human and mouse Kv1.3 voltage-gated potassium channels (IC50s = 11.8 and 13.2 µM, respectively). Overexpression of beta-defensin-1 in the human oral squamous cell carcinoma (OSCC) cell lines HSC-3, UM-1, and SCC-9 increases migration and invasion but not proliferation.Synonyms: hBD-1. Molecular Formula: C167H256N48O50S6 . XCF3COOH. Formula Weight: 3928.5. Purity: >95%. Formulation: (Request formulation change), A lyophilized powder. Solubility: Water: 1 mg/ml. SMILES: [H]N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CC(N)=O)C(N[C@H](C(N[C@@H](C(C)C)C(N[C@@H](CO)C(N[C@@H](CO)C(NCC(NCC(N[C@@H](CCC(N)=O)C(N[C@H](C(N[C@@H](CC(C)C)C(N[C@H](C(N[C@@H](CO)C(N[C@H](C(N[C@H](C(N1CCC[C@H]1C(N[C@]([C@H](CC)C)([H])C(N[C@H](C(N[C@]([C@@H](C)O)([H])C(N[C@@H](CCCCN)C(N[C@]([C@H](CC)C)([H])C(N[C@@H](CCC(N)=O)C(NCC(N[C@]([C@@H](C)O)([H])C2=O)=O)=O)=O)=O)=O)=O)CC3=CC=CC=C3)=O)=O)=O)CSSC[C@H](N4)C(N[C@@H](CCCCN)C(O)=O)=O)=O)C)=O)=O)CC5=CC=C(O)C=C5)=O)=O)CSSC[C@H](N2)C(N[C@H](C(N[C@@H](CCCNC(N)=N)C(NCC(N[C@@H](CCCCN)C(N[C@H](C(N[C@@H](CCCCN)C6=O)=O)C)=O)=O)=O)=O)CC7=CC=C(O)C=C7)=O)=O)=O)=O)=O)=O)=O)=O)CSSC[C@H](N6)C4=O)=O)=O)CC8=CC=C(O)C=C8)=O)CC9=CN=CN9)=O)CC(O)=O.FC(F)(C(O)=O)F. InChi Code: InChI=1S/C167H256N48O50S6.C2HF3O2/c1-13-83(7)131-161(259)192-102(48-50-122(173)224)139(237)183-70-128(230)210-133(87(11)219)163(261)208-118-77-268-266-75-116-155(253)195-105(58-81(3)4)145(243)196-108(62-92-40-46-96(223)47-41-92)148(246)202-113(72-217)152(250)186-86(10)136(234)209-120(165(263)215-57-27-35-121(215)159(257)213-132(84(8)14-2)162(260)200-109(59-89-28-16-15-17-29-89)151(249)214-134(88(12)220)164(262)191-101(144(242)212-131)32-20-24-54-170)79-271-270-74-115(154(252)193-104(166(264)265)33-21-25-55-171)207-157(255)117(204-142(240)100(31-19-23-53-169)189-135(233)85(9)185-141(239)99(30-18-22-52-168)187-127(229)69-182-138(236)98(34-26-56-179-167(176)177)190-146(244)106(198-156(118)254)60-90-36-42-94(221)43-37-90)76-267-269-78-119(158(256)211-130(82(5)6)160(258)203-114(73-218)153(251)201-112(71-216)140(238)181-67-125(227)180-68-126(228)188-103(143(241)205-116)49-51-123(174)225)206-150(248)111(65-124(175)226)199-147(245)107(61-91-38-44-95(222)45-39-91)197-149(247)110(63-93-66-178-80-184-93)194-137(235)97(172)64-129(231)232,3-2(4,5)1(6)7/h15-17,28-29,36-47,66,80-88,97-121,130-134,216-223H,13-14,18-27,30-35,48-65,67-79,168-172H2,1-12H3,(H2,173,224)(H2,174,225)(H2,175,226)(H,178,184)(H,180,227)(H,181,238)(H,182,236)(H,183,237)(H,185,239)(H,186,250)(H,187,229)(H,188,228)(H,189,233)(H,190,244)(H,191,262)(H,192,259)(H,193,252)(H,194,235)(H,195,253)(H,196,243)(H,197,247)(H,198,254)(H,199,245)(H,200,260)(H,201,251)(H,202,246)(H,203,258)(H,204,240)(H,205,241)(H,206,248)(H,207,255)(H,208,261)(H,209,234)(H,210,230)(H,211,256)(H,212,242)(H,213,257)(H,214,249)(H,231,232)(H,264,265)(H4,176,177,179),(H,6,7)/t83-,84-,85-,86-,87+,88+,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,130-,131-,132-,133-,134-,/m0./s1. InChi Key: HBBMHBBHKASVTH-GAERLICXSA-N.
Schlagworte: hBD-1
Hersteller: Cayman Chemical
Hersteller-Nr: 24576

Eigenschaften

Konjugat: No
MW: 3928.5 D
Formel: C167H256N48O50S6 . XCF3COOH
Reinheit: >95%
Format: Solid

Datenbank Information

UniProt ID : P60022 | Passende Produkte
Gene ID GeneID 1672 | Passende Produkte

Handhabung & Sicherheit

Lagerung: -20°C
Versand: +20°C (International: -20°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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