Antisauvagine-30 (trifluoroacetate salt)

Antisauvagine-30 (trifluoroacetate salt)
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
Cay34271-500 500 µg -

6 - 10 Werktage*

312,00 €
Cay34271-1 1 mg -

6 - 10 Werktage*

560,00 €
 
Antisauvagine-30 is a peptide antagonist of corticotropin-releasing factor receptor 2 (CRF2). It... mehr
Produktinformationen "Antisauvagine-30 (trifluoroacetate salt)"
Antisauvagine-30 is a peptide antagonist of corticotropin-releasing factor receptor 2 (CRF2). It is selective for CRF2alpha over CRF1 (Kis = 1.75 and 915 nM, respectively for the human receptors). Antisauvagine-30 (10 nM) inhibits sauvagine-induced cAMP production in HEK293 cells expressing mouse CRF2beta. It prevents stress-induced contextual fear conditioning in mice. Antisauvagine-30 reduces vasoactive intestinal peptide-induced decreases in food intake in rats.Formal Name: D-phenylalanyl-L-histidyl-L-leucyl-L-leucyl-L-arginyl-L-lysyl-L-methionyl-L-isoleucyl-L-alpha-glutamyl-L-isoleucyl-L-alpha-glutamyl-L-lysyl-L-glutaminyl-L-alpha-glutamyl-L-lysyl-L-alpha-glutamyl-L-lysyl-L-glutaminyl-L-glutaminyl-L-alanyl-L-alanyl-L-asparaginyl-L-asparaginyl-L-arginyl-L-leucyl-L-leucyl-L-leucyl-L-alpha-aspartyl-L-threonyl-L-isoleucinamide, trifluoroacetate salt. Synonyms: AS30, D-FHLLRKMIEIEKNEKEKNNAANNRLLLDTI-NH2, [D-Phe11,His12]Svg11-40, aSVG, aSvg-30. Molecular Formula: C161H274N48O46S . XCF3COOH. Formula Weight: 3650.3. Purity: >95%. Formulation: A solid. Solubility: Water: soluble. SMILES: O=C([C@@H](CC1=CC=CC=C1)N)N[C@H](C(N[C@@H](CC(C)C)C(N[C@@H](CC(C)C)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@]([H])([C@H](CC)C)C(N[C@H](C(N[C@@]([H])([C@H](CC)C)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](C)C(N[C@@H](C)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CC(C)C)C(N[C@@H](CC(C)C)C(N[C@@H](CC(C)C)C(N[C@H](C(N[C@]([H])(C(N[C@@]([H])([C@H](CC)C)C(N)=O)=O)[C@@H](C)O)=O)CC(O)=O)=O)=O)=O)=O)CCCNC(N)=N)=O)CC(N)=O)=O)CC(N)=O)=O)=O)=O)CCC(N)=O)=O)CCC(N)=O)=O)CCCCN[H])=O)CCC(O)=O)=O)CCCCN[H])=O)CCC(O)=O)=O)CCC(N)=O)=O)CCCCN[H])=O)CCC(O)=O)=O)=O)CCC(O)=O)=O)=O)CCSC)=O)CCCCN[H])=O)CCCNC(N)=N)=O)=O)=O)CC2=CNC=N2.OC(C(F)(F)F)=O. InChi Code: InChI=1S/C161H274N48O46S.C2HF3O2/c1-21-84(14)126(130(172)226)206-159(255)129(89(19)210)209-156(252)115(76-125(224)225)205-152(248)111(71-83(12)13)202-150(246)109(69-81(8)9)201-149(245)108(68-80(6)7)199-140(236)98(44-36-65-179-161(175)176)188-154(250)114(75-120(171)215)204-155(251)113(74-119(170)214)197-132(228)88(18)181-131(227)87(17)182-134(230)99(45-52-116(167)211)189-141(237)100(46-53-117(168)212)190-135(231)93(39-27-31-60-162)184-143(239)102(48-55-121(216)217)192-137(233)95(41-29-33-62-164)185-144(240)103(49-56-122(218)219)193-142(238)101(47-54-118(169)213)191-136(232)94(40-28-32-61-163)186-145(241)104(50-57-123(220)221)195-157(253)127(85(15)22-2)207-146(242)105(51-58-124(222)223)196-158(254)128(86(16)23-3)208-147(243)106(59-66-256-20)194-138(234)96(42-30-34-63-165)183-139(235)97(43-35-64-178-160(173)174)187-148(244)107(67-79(4)5)200-151(247)110(70-82(10)11)203-153(249)112(73-91-77-177-78-180-91)198-133(229)92(166)72-90-37-25-24-26-38-90,3-2(4,5)1(6)7/h24-26,37-38,77-89,92-115,126-129,210H,21-23,27-36,39-76,162-166H2,1-20H3,(H2,167,211)(H2,168,212)(H2,169,213)(H2,170,214)(H2,171,215)(H2,172,226)(H,177,180)(H,181,227)(H,182,230)(H,183,235)(H,184,239)(H,185,240)(H,186,241)(H,187,244)(H,188,250)(H,189,237)(H,190,231)(H,191,232)(H,192,233)(H,193,238)(H,194,234)(H,195,253)(H,196,254)(H,197,228)(H,198,229)(H,199,236)(H,200,247)(H,201,245)(H,202,246)(H,203,249)(H,204,251)(H,205,248)(H,206,255)(H,207,242)(H,208,243)(H,209,252)(H,216,217)(H,218,219)(H,220,221)(H,222,223)(H,224,225)(H4,173,174,178)(H4,175,176,179),(H,6,7)/t84-,85-,86-,87-,88-,89+,92+,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,113-,114-,115-,126-,127-,128-,129-,/m0./s1. InChi Key: FHZQYUPGDABGJW-NDMSIQOJSA-N.
Schlagworte: [D-Phe11,His12]Svg11-40, AS30, aSVG, aSvg-30, D-FHLLRKMIEIEKNEKEKNNAANNRLLLDTI-NH2, D-phenylalanyl-L-histidyl-L-leucyl-L-leucyl-L-arginyl-L-lysyl-L-methionyl-L-isoleucyl-L-alpha-glutamyl-L-isoleucyl-L-alpha-glutamyl-L-lysyl-L-glutaminyl-L-alpha-glutamyl-L
Hersteller: Cayman Chemical
Hersteller-Nr: 34271

Eigenschaften

Anwendung: Peptide CRF2 antagonist
Konjugat: No
MW: 3650.3 D
Formel: C161H274N48O46S . XCF3COOH
Reinheit: >95%
Format: Solid

Datenbank Information

KEGG ID : K04579 | Finde Alternativen

Handhabung & Sicherheit

Lagerung: -20°C
Versand: +20°C (International: -20°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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