Antagonist G (trifluoroacetate salt)

Antagonist G (trifluoroacetate salt)
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
Cay34425-1 1 mg -

6 - 10 Werktage*

279,00 €
Cay34425-5 5 mg -

6 - 10 Werktage*

1.238,00 €
Cay34425-10 10 mg -

6 - 10 Werktage*

2.197,00 €
 
Antagonist G is a neuropeptide antagonist. It inhibits the binding of vasopressin to rat liver or... mehr
Produktinformationen "Antagonist G (trifluoroacetate salt)"
Antagonist G is a neuropeptide antagonist. It inhibits the binding of vasopressin to rat liver or Swiss 3T3 membranes (IC50s = 3.5 and 2.2 µM, respectively) and vasopressin-induced production of inositol phosphate in Swiss 3T3 fibroblasts (IC50 = 1 µM). Antagonist G (50 µM) induces apoptosis and the production of reactive oxygen species (ROS) in NCI H69 small cell lung cancer (SCLC) cells. It reduces tumor growth in an NCI H69 mouse xenograft model when administered at a dose of 45 µg/g.Formal Name: L-arginyl-D-tryptophyl-N-methyl-L-phenylalanyl-D-tryptophyl-L-leucyl-L-methioninamide, trifluoroacetate salt. Synonyms: Arg-D-Trp-NmePhe-D-Trp-Leu-Met-NH2, [Arg6,D-Trp7,9,NmePhe8]-substance P (6-11). Molecular Formula: C49H66N12O6S . XCF3COOH. Formula Weight: 951.2. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, DMSO:PBS (pH 7.2) (1:3): 0.25 mg/ml, Ethanol: 20 mg/ml. lambdamax: 220 nm. SMILES: CSCC[C@@H](C(N)=O)NC([C@H](CC(C)C)NC([C@@H](CC1=CNC2=CC=CC=C12)NC([C@H](CC3=CC=CC=C3)N(C)C([C@H](NC([C@@H](N)CCCNC(N)=N)=O)CC4=CNC5=CC=CC=C45)=O)=O)=O)=O.OC(C(F)(F)F)=O. InChi Code: InChI=1S/C49H66N12O6S.C2HF3O2/c1-29(2)23-39(45(64)57-38(43(51)62)20-22-68-4)58-46(65)40(25-31-27-55-36-18-10-8-15-33(31)36)59-47(66)42(24-30-13-6-5-7-14-30)61(3)48(67)41(26-32-28-56-37-19-11-9-16-34(32)37)60-44(63)35(50)17-12-21-54-49(52)53,3-2(4,5)1(6)7/h5-11,13-16,18-19,27-29,35,38-42,55-56H,12,17,20-26,50H2,1-4H3,(H2,51,62)(H,57,64)(H,58,65)(H,59,66)(H,60,63)(H4,52,53,54),(H,6,7)/t35-,38-,39-,40+,41+,42-,/m0./s1. InChi Key: GUDATFWCKFMCTO-RGVCNNQFSA-N.
Schlagworte: [Arg6,D-Trp7,9,NmePhe8]-substance P (6-11), Arg-D-Trp-NmePhe-D-Trp-Leu-Met-NH2, (S)-N-((5S,8S,11R,14S,17R)-11-((1H-indol-3-yl)methyl)-14-benzyl-5-carbamoyl-18-(1H-indol-3-yl)-8-isobutyl-15-methyl-7,10,13,16-tetraoxo-2-thia-6,9,12,15-tetraazaoctadecan-17-y
Hersteller: Cayman Chemical
Hersteller-Nr: 34425

Eigenschaften

Anwendung: Neuropeptide antagonist
Konjugat: No
MW: 951.2 D
Formel: C49H66N12O6S . XCF3COOH
Reinheit: >98%
Format: Solid

Datenbank Information

KEGG ID : K05242 | Passende Produkte

Handhabung & Sicherheit

Lagerung: -20°C
Versand: +20°C (International: -20°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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