alpha-NAAG

alpha-NAAG is a peptide neurotransmitter that is widely expressed throughout mammalian central and peripheral nervous systems. Following synaptic release, alpha-NAAG activates postsynaptic metabotropic glutamate receptor 3 (mGluR3) to inhibit cAMP production in neurons and astrocytes, as well as acts on presynaptic mGluR3 to inhibit the release of amine neurotransmitters, including GABA and glutamate. Increasing alpha-NAAG levels via NAAG peptidase inhibition reduces trauma-induced excitotoxic cell death in a mouse model of traumatic brain injury, as well as reduces hyperalgesia in various rodent pain models and schizophrenia-like stereotypic behaviors induced by phencyclidine in rats. Tumor levels of alpha-NAAG are positively correlated with tumor grade in patients with gliomas and meningiomas.Formal Name: N-acetyl-alpha-L-aspartyl-L-glutamic acid. CAS Number: 3106-85-2. Synonyms: NAAG, N-Acetylaspartylglutamic Acid, alpha-Spaglumic Acid. Molecular Formula: C11H16N2O8. Formula Weight: 304.3. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: DMF: 20 mg/ml, DMSO: 20 mg/ml, Ethanol: 20 mg/ml, PBS (pH 7.2): 10 mg/ml. SMILES: OC(CC[C@@H](C(O)=O)NC([C@@H](NC(C)=O)CC(O)=O)=O)=O. InChi Code: InChI=1S/C11H16N2O8/c1-5(14)12-7(4-9(17)18)10(19)13-6(11(20)21)2-3-8(15)16/h6-7H,2-4H2,1H3,(H,12,14)(H,13,19)(H,15,16)(H,17,18)(H,20,21)/t6-,7-/m0/s1. InChi Key: OPVPGKGADVGKTG-BQBZGAKWSA-N.