HIF-1alpha (C-Term) Blocking Peptide

To be used in conjunction with Cayman's HIF-1alpha Polyclonal Antibody (Cay-10006421) to block protein-antibody complex formation during immunochemical analysis of HIF-1alpha. HIF-1alpha is a transcription factor that accumulates under low-oxygen conditions. Following hypoxic stimulus and cytoplasmic accumulation, HIF-1alpha migrates to the nucleus where, with other transcription factors, it drives the production of stress-adaptive proteins. This response is essential for maintenance of normal oxidative physiology, however HIF-1alpha overexpression in cancer cells promotes tumor survival. HIF-1alpha is an EPAS-1 family member with phosphorylation dependent activities. HIF-1alpha will migrate to the apparent molecular weights of 110-125 kDa (by SDS-PAGE) depending on phosphorylation status.Synonyms: ARNT-interacting Protein, Hypoxia-Inducible Factor-1alpha. Formulation: (Request formulation change), 200 µg of lyophilized peptide.