Scavenger Receptor B2/CD36 Blocking Peptide

To be used in conjunction with Cayman's CD36 polyclonal antibody (Cay-100011) to block protein-antibody complex formation during immunochemical analysis of CD36. CD36 is a type-B scavenger receptor that is necessary for the formation of foam cells in atherosclerotic lesions.{7719,9800, 9801,9795} This membrane glycoprotein can internalize fatty acids which activate PPARgamma and stimulate further expression of CD36. This positive feedback loop combined with the murine CD36 knock-out studies reinforces the importance of CD36 in lipid metabolism. Additionally CD36 is needed for the phagocytosis of P. falciparum infected erythrocytes, retinal pigment epithelial cell photoreceptor fragments, and post-apoptotic monocytes and neutrophils. CD36 expression has been monitored during hematopoietic cell differentiation and may be an indicator of tumor spreading in lymphocytic leukemia. This transmembrane glycoprotein is detected by immunoblotting at 88 kDa or 54 kDa depending on the degree of glycosylation of the receptor in your sample. Positive controls include adipose and heart tissue, platelets, and macrophages.Synonyms: Fatty Acid Translocase, GPIIIb, GPIV, PAS IV, Platelet Collagen Receptor, Platelet Glycoprotein 4, Thrombospondin Receptor. Amino Acids: Human CD36 sequence amino acids 98-114 (AKENVTQDAEDNTVSF). Formulation: (Request formulation change), 200 µg of lyophilized peptide.