tetranor-PGEM-d6

tetranor-PGEM-d6
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
Cay314840-25 25 µg -

3 - 10 Werktage*

274,00 €
Cay314840-50 50 µg -

3 - 10 Werktage*

520,00 €
Cay314840-100 100 µg -

3 - 10 Werktage*

985,00 €
 
Tetranor prostaglandin E metabolite-d6 (tetranor-PGEM-d6) contains six deuterium atoms at the 13,... mehr
Produktinformationen "tetranor-PGEM-d6"
Tetranor prostaglandin E metabolite-d6 (tetranor-PGEM-d6) contains six deuterium atoms at the 13, 13, 14, 14, 15, and 15 positions. It is intended for use as an internal standard for the quantification of tetranor PGEM by GC- or LC-mass spectrometry. Tetranor PGEM-d6 is the major urinary metabolite of PGE1 and PGE2. It is used as a urinary marker of PGE2 biosynthesis, and to monitor metabolism after infusion or injection of PGE1 as a pharmaceutical. Normal healthy males excrete 16-30 µg of tetranor PGEM over a 24-hour period. Females excrete less by about a factor of three. Following oral administration (4 x 50 mg/24 hours) of the COX inhibitor, indomethacin, urinary levels of tetranor PGEM decrease by 75-98% indicating the almost complete loss of PGE2 biosynthesis. Formal Name: 9,15-dioxo-11alpha-hydroxy-13,14-dihydro-2,3,4,5-tetranor-prostan-13,13,14,14,15,15-d6-1,20-dioic acid. CAS Number: 1240398-16-6. Synonyms: tetranor-Prostaglandin E Metabolite-d6. Molecular Formula: C16H18D6O7. Formula Weight: 334.4. Purity: >99% deuterated forms (may contain d4-d8). Formulation: A solution in methyl acetate. Solubility: DMF: 50 mg/ml, DMSO: 50 mg/ml, Ethanol: Not Stable, PBS (pH 7.2): 1 mg/ml. SMILES: O=C1[C@H](CCC(O)=O)[C@@H](CCC(CC([2H])([2H])C([2H])([2H])C([2H])([2H])C(O)=O)=O)[C@H](O)C1. InChi Code: InChI=1S/C16H24O7/c17-10(3-1-2-4-15(20)21)5-6-11-12(7-8-16(22)23)14(19)9-13(11)18/h11-13,18H,1-9H2,(H,20,21)(H,22,23)/t11-,12-,13-/m1/s1/i1D2,2D2,4D2. InChi Key: ZJAZCYLYLVCSNH-VFBFAAMGSA-N.
Schlagworte: tetranor-Prostaglandin E Metabolite-d6, 9,15-dioxo-11alpha-hydroxy-13,14-dihydro-2,3,4,5-tetranor-prostan-13,13,14,14,15,15-d6-1,20-dioic acid
Hersteller: Cayman Chemical
Hersteller-Nr: 314840

Eigenschaften

Anwendung: Standard
MW: 334.4 D
Formel: C16H18D6O7
Reinheit: >99% deuterated forms (may contain d4-d8)
Format: Solution

Datenbank Information

CAS : 1240398-16-6| Finde Alternativen

Handhabung & Sicherheit

Lagerung: -80°C
Versand: -20°C (International: -80°C)
Signalwort: Danger
GHS-Piktogramme:
H-Sätze: EUH066, H225, H319, H336
P-Sätze: , P210, P233, P240, P241, P242, P243, P261, P264, P271, P280, P303+361+353, P304+340, P305+351+338, P312, P337+313, P370+378, P403+233, P403+235, P405, P501
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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