Sphingosine-1-phosphate

Sphingosine-1-phosphate
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
Cay62570-1 1 mg -

5 - 10 Werktage*

75,00 €
Cay62570-5 5 mg -

5 - 10 Werktage*

282,00 €
Cay62570-10 10 mg -

5 - 10 Werktage*

450,00 €
Cay62570-25 25 mg -

5 - 10 Werktage*

900,00 €
 
Sphingosine-1-phosphate (S1P) is the product of phosphorylation of sphingosine by sphingosine... mehr
Produktinformationen "Sphingosine-1-phosphate"
Sphingosine-1-phosphate (S1P) is the product of phosphorylation of sphingosine by sphingosine kinase that is secreted from cells and acts as an agonist at S1P receptors. It increases intracellular calcium levels in TAg-Jurkat cells expressing S1P1 and Gqi5, which allows for phospholipase C stimulation by Gi proteins, when used at a concentration of 200 nM, as well as in TAg-Jurkat cells expressing S1P2 and S1P3 receptors (EC50s = 8 and 11 nM, respectively). Intra- and extracellular levels of S1P vary spatially allowing it to function as an autocrine or paracrine factor, respectively, and dysregulation of S1P levels are associated with various disease states, such as inflammation and autoimmunity. S1P has a wide variety of effects, including an involvement in cell growth, angiogenesis, immunity, and neuroprotection. Formal Name: 2S-amino-4E-octadecene-1,3R-diol 1-(dihydrogen phosphate). CAS Number: 26993-30-6. Synonyms: S1P (d18:1), Sphingosine-1-Phosphoric Acid. Molecular Formula: C18H38NO5P. Formula Weight: 379.5. Purity: >98%. Formulation: A crystalline solid. Solubility: .3 M NaOH: 4 mg/ml, DMF: <50 µg/ml, DMSO: <50 µg/ml, PBS pH 7.2: <50 µg/ml. SMILES: CCCCCCCCCCCCC/C=C/[C@@H](O)[C@@H](N)COP(O)(O)=O. InChi Code: InChI=1S/C18H38NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h14-15,17-18,20H,2-13,16,19H2,1H3,(H2,21,22,23)/b15-14+/t17-,18+/m0/s1. InChi Key: DUYSYHSSBDVJSM-KRWOKUGFSA-N.
Schlagworte: S1P (d18:1), Sphingosine-1-Phosphoric Acid, 2S-amino-4E-octadecene-1,3R-diol 1-(dihydrogen phosphate)
Hersteller: Cayman Chemical
Hersteller-Nr: 62570

Eigenschaften

Anwendung: Bioactive lipid assays
MW: 379.5 D
Formel: C18H38NO5P
Reinheit: >98%
Format: Crystalline Solid

Datenbank Information

CAS : 26993-30-6| Finde Alternativen

Handhabung & Sicherheit

Lagerung: -20°C
Versand: +20°C (International: -20°C)
Signalwort: Warning
GHS-Piktogramme:
H-Sätze: H315, H319, H335
P-Sätze: P261, P264, P271, P280, P302+352, P304+340, P305+351+338, P312, P321, P332+313, P337+313, P362+364, P403+233, P405, P501
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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