Rutaecarpine

Rutaecarpine is a quinazolinone alkaloid originally isolated from E. rutaecarpa that has diverse biological activities. It inhibits COX-1 and COX-2 in BMMC cells (IC50s = 8.7 and 0.28 µM, respectively) and is selective for COX-2 in HEK293 cells (IC50s = >400 and 2.8 µM, for COX-1 and COX-2, respectively). It slows the growth of cancer cells in vitro with GI50 values of 8.41-31.6 µM. It also has cardiovascular properties, inducing dose-dependent vasodilation (0.1-10 µM) of precontracted isolated rat aorta and inhibiting platelet aggregation. In addition, rutaecarpine (80 mg/kg) decreases plasma levels of caffeine in rat by inducing its metabolism through the cytochrome P450 (CYP) isoforms CYP1A2 and CYP2E1.Formal Name: 8,13-dihydro-indolo[2',3':3,4]pyrido[2,1-b]quinazolin-5(7H)-one. CAS Number: 84-26-4. Synonyms: NSC 258317. Molecular Formula: C18H13N3O. Formula Weight: 287.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 33 mg/ml, DMSO: 12 mg/ml. lambdamax: 213, 345, 362 nm. SMILES: O=C1C2=CC=CC=C2N=C3N1CCC4=C3NC5=C4C=CC=C5. InChi Code: InChI=1S/C18H13N3O/c22-18-13-6-2-4-8-15(13)20-17-16-12(9-10-21(17)18)11-5-1-3-7-14(11)19-16/h1-8,19H,9-10H2. InChi Key: ACVGWSKVRYFWRP-UHFFFAOYSA-N.