PtdIns-(3,4)-P2 (1,2-dioctanoyl) (sodium salt)

The phosphatidylinositols (PtdIns) represent a small percentage of total membrane phospholipids. However, they play a critical role in the generation and transmission of cellular signals. PtdIns-(3,4)-P2 (1,2-dioctanoyl) is a synthetic analog of natural PtdIns featuring C8:0 fatty acids at the sn-1 and sn-2 positions. The compound contains the same inositol and diacylglycerol (DAG) stereochemistry as the natural compound. The natural compound is the product of phosphorylation-dephosphorylation involving PtdIn 3-kinase and 5-phosphatases. The 3D-phosphorylated PtdIns are resistant to hydrolysis by phospholipase C.Formal Name: 1-(1,2R-dioctanoylphosphatidyl)inositol-3,4-bisphosphate, trisodium salt. Synonyms: DOPI-3,4-P2, Phosphatidylinositol-3,4-bisphosphate C-8, PI(3,4)P2 (8:0/8:0), PIP2[3',4'](8:0/8:0). Molecular Formula: C25H46O19P3 . 3Na. Formula Weight: 812.5. Purity: >98%. Formulation: (Request formulation change), A lyophilized powder. Solubility: Water: 10 mg/ml. SMILES: O[C@H]1[C@H](OP([O-])(O)=O)[C@@H](O[P+]([O-])(O)=O)[C@@H](O)[C@@H](OP(OC[C@H](OC(CCCCCCC)=O)COC(CCCCCCC)=O)([O-])=O)[C@@H]1O.[Na+].[Na+].[Na]. InChi Code: InChI=1S/C25H49O19P3.3Na/c1-3-5-7-9-11-13-18(26)39-15-17(41-19(27)14-12-10-8-6-4-2)16-40-47(37,38)44-23-20(28)21(29)24(42-45(31,32)33)25(22(23)30)43-46(34,35)36,,,/h17,20-25,28-30H,3-16H2,1-2H3,(H,37,38)(H2,31,32,33)(H2,34,35,36),,,/q,3*+1/p-3/t17-,2. InChi Key: WIFRKINRFJNHBB-CCPODLHSSA-K. Side Chain Carbon Sum: 16:0.