Prostaglandin F2alpha 1,11-lactone

PGF2alpha 1,11-lactone is a lipid-soluble internal ester of PGF2alpha. Hydrolysis of the lactone by plasma esterases readily produces free PGF2alpha in rats and monkeys, but not in humans. PGF2alpha 1,11-lactone is active as an antifertility agent with greatly reduced vasoactivity compared to PGF2alpha. Formal Name: 9alpha,11alpha,15S-trihydroxy-prosta-5Z,13E-dien-1-oic acid, 1,11-lactone. CAS Number: 62410-84-8. Synonyms: PGF2alpha 1,11-lactone. Molecular Formula: C20H32O4. Formula Weight: 336.5. Purity: >98%. Formulation: A solution in methyl acetate. Solubility: DMF: >20 mg/ml (from PGF2a 1,15-lac, DMSO: >10 mg/ml (from PGF2a 1,15-lac, Ethanol: >100 mg/ml (from PGF2a 1,15-la, Ethanol:PBS (30:70): 8 mg/ml, PBS pH 7.2: <50 µg/ml (from PGF2a 1,15-lac. SMILES: O[C@H]1C[C@@H]2[C@H](/C=C/[C@@H](O)CCCCC)[C@H]1C/C=C\CCCC(O2)=O. InChi Code: InChI=1S/C20H32O4/c1-2-3-6-9-15(21)12-13-17-16-10-7-4-5-8-11-20(23)24-19(17)14-18(16)22/h4,7,12-13,15-19,21-22H,2-3,5-6,8-11,14H2,1H3/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1. InChi Key: KBFCVOAVUKWCPS-YNNPMVKQSA-N.