Prostaglandin E2 methyl ester

Prostaglandin E2 methyl ester (PGE2 methyl ester) is an analog of PGE2 (Cay-14010) with enhanced lipid solubility. PGE2 is one of the primary cyclooxygenase products of arachidonic acid (Cay-90010) and one of the most widely investigated PGs. Its activity influences inflammation, fertility and parturition, gastric mucosal integrity, and immune modulation. The effects of PGE2 are transduced by at least four distinct receptors designated EP1, EP2, EP3, and EP4. Affinity constants (Kd) values of PGE2 for these receptors range from 1-10 nM depending on the receptor subtype and tissue.Formal Name: 9-oxo-11alpha,15S-dihydroxy-prosta-5Z,13E-dien-1-oic acid, methyl ester. CAS Number: 31753-17-0. Synonyms: Dinoprostone methyl ester, PGE2 methyl ester. Molecular Formula: C21H34O5. Formula Weight: 366.5. Purity: >98%. Formulation: (Request formulation change), A solution in methyl acetate. Solubility: DMF: 25 mg/ml, DMSO: 30 mg/ml, Ethanol: 50 mg/ml, PBS (pH 7.2): 150 µg/ml. SMILES: O=C1[C@H](C/C=C\CCCC(OC)=O)[C@@H](/C=C/[C@@H](O)CCCCC)[C@H](O)C1. InChi Code: InChI=1S/C21H34O5/c1-3-4-7-10-16(22)13-14-18-17(19(23)15-20(18)24)11-8-5-6-9-12-21(25)26-2/h5,8,13-14,16-18,20,22,24H,3-4,6-7,9-12,15H2,1-2H3/b8-5-,14-13+/t16-,17+,18+,20+/m0/s1. InChi Key: WGCXTGBZBFBQPP-ZYONDNFOSA-N.