Piroxicam-d3

Piroxicam-d3 is intended for use as an internal standard for the quantification of piroxicam (Cay-13368) by GC- or LC-MS. Piroxicam is a COX inhibitor and non-steroidal anti-inflammatory drug (NSAID) with anti-inflammatory and analgesic properties. It inhibits production of thromboxane B2 (TXB2, Cay-19030) from arachidonic acid (Cay-90010, Cay-90010.1, Cay-10006607) in HEL human erythroleukemic cells (IC50 = 0.45 µM), which endogenously express COX-1, as well as inhibits LPS-induced formation of prostaglandin F1alpha (PGF1alpha, Cay-15010) from arachidonic acid in Mono-Mac-6 cells (IC50 = 0.77 µM), which endogenously express COX-2. Lornoxicam reduces LPS-induced production of nitric oxide and IL-6 in cell-based assays with IC50 values of 240 and ~470 µM, respectively. It reduces carrageenan-induced paw edema in rats when administered at doses of 1, 2.5, and 5 mg/kg. Formulations containing piroxicam have been used in the treatment of pain and inflammation associated with osteoarthritis and rheumatoid arthritis.Formal Name: 1,1-dioxide-4-hydroxy-2-(methyl-d3)-N-2-pyridinyl-2H-1,2-benzothiazine-3-carboxamide. CAS Number: 942047-64-5. Molecular Formula: C15H10D3N3O4S. Formula Weight: 334.4. Purity: >99% deuterated forms (d1-d3). Formulation: (Request formulation change), A solid. Solubility: Methanol: soluble. SMILES: OC(C1=CC=CC=C12)=C(C(NC3=CC=CC=N3)=O)N(C([2H])([2H])[2H])S2(=O)=O. InChi Code: InChI=1S/C15H13N3O4S/c1-18-13(15(20)17-12-8-4-5-9-16-12)14(19)10-6-2-3-7-11(10)23(18,21)22/h2-9,19H,1H3,(H,16,17,20)/i1D3. InChi Key: QYSPLQLAKJAUJT-FIBGUPNXSA-N.