PAF C-18

PAF C-18 is a naturally occurring phospholipid produced upon stimulation through two distinct pathways known as the "remodeling" and 'de novo' pathways. It is less potent than PAF C-16 in the induction of platelet aggregation, but equipotent in activation of guinea pig macrophages. PAF C-18 induces the release of PGE2 and TXB2 from albumin-elicited guinea pig macrophages, and enhances the spreading of plated macrophages. Pathological processes involving PAF include necrotizing enterocolitis, inflammation, asthma, and allergy.Formal Name: 1-O-octadecyl-2-O-acetyl-sn-glyceryl-3-phosphorylcholine. CAS Number: 74389-69-8. Molecular Formula: C28H58NO7P. Formula Weight: 551.7. Purity: >97%. Formulation: (Request formulation change), A solution in ethanol. Solubility: DMF: 10 mg/ml, DMSO: 10 mg/ml, Ethanol: 10 mg/ml, PBS pH 7.2: 20 mg/ml, Water: 20 mg/ml. SMILES: CCCCCCCCCCCCCCCCCCOC[C@@H](OC(C)=O)COP(OCC[N+](C)(C)C)([O-])=O. InChi Code: InChI=1S/C28H58NO7P/c1-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-23-33-25-28(36-27(2)30)26-35-37(31,32)34-24-22-29(3,4)5/h28H,6-26H2,1-5H3/t28-/m1/s1. InChi Key: ZXCIEWBDUAPBJF-MUUNZHRXSA-N. Side Chain Carbon Sum: 20:0.