Nimesulide-d5

Nimesulide-d5 is intended for use as an internal standard for the quantification of nimesulide (Cay-70640) by GC- or LC-MS. Nimesulide is a non-steroidal anti-inflammatory drug (NSAID) and COX-2 inhibitor (IC50s = 1.27 and 0.03 µM for the human and ovine enzymes, respectively). It is selective for COX-2 over COX-1 (IC50s = 70 and 22 µM for the human and ovine enzymes, respectively). Nimesulide also inhibits sodium-dependent neutral amino acid transporter (B0AT1) with an IC50 value of 23 µM for the rat kidney transporter. It inhibits infection-induced increases in brain prostaglandin E2 (PGE2, Cay-14010) levels, as well as reduces pyresis (ED50 = 0.3 mg/kg), in yeast-infected rats. Nimesulide (2.9 mg/kg) inhibits formalin-induced hindpaw thermal hyperalgesia in rats.Formal Name: N-(4-nitro-2-(phenoxy-d5)phenyl)methanesulfonamide. CAS Number: 1330180-22-7. Synonyms: R805-d5. Molecular Formula: C13H7D5N2O5S. Formula Weight: 313.3. Purity: >99% deuterated forms (d1-d5). Formulation: (Request formulation change), A solid. Solubility: Methanol: soluble. SMILES: CS(NC(C=CC([N+]([O-])=O)=C1)=C1OC2=C([2H])C([2H])=C([2H])C([2H])=C2[2H])(=O)=O. InChi Code: InChI=1S/C13H12N2O5S/c1-21(18,19)14-12-8-7-10(15(16)17)9-13(12)20-11-5-3-2-4-6-11/h2-9,14H,1H3/i2D,3D,4D,5D,6D. InChi Key: HYWYRSMBCFDLJT-VIQYUKPQSA-N.