N-Cyclohexanecarbonylpentadecylamine

Numerous analogs of fatty acyl ethanolamides potentiate the intrinsic biological activity of endocannabinoids. This potentiation is ascribed either to inhibition of AEA reuptake into neurons, or inhibition of fatty acid amide hydrolase (FAAH) within the neurons. However, Ueda has recently cloned another amidase, the acidic palmitoyl ethanolamidase (PEAase) that promotes the hydrolysis of palmitoylethanolamide. N-Cyclohexanecarbonylpentadecylamine is a selective inhibitor of acidic PEAase, inhibiting the enzyme with an IC50 of 4.5 µM, while failing to inhibit FAAH even at 100 µM.Formal Name: N-pentadecyl-cyclohexanecarboxamide. CAS Number: 702638-84-4. Molecular Formula: C22H43NO. Formula Weight: 337.6. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: Ethanol: 2 mg/ml. SMILES: CCCCCCCCCCCCCCCNC(=O)C1CCCCC1. InChi Code: InChI=1S/C22H43NO/c1-2-3-4-5-6-7-8-9-10-11-12-13-17-20-23-22(24)21-18-15-14-16-19-21/h21H,2-20H2,1H3,(H,23,24). InChi Key: VMFXYTSKMWPHQH-UHFFFAOYSA-N.