I-SAP

I-SAP is a high affinity TP receptor antagonist. At physiologic pH, I-SAP produces platelet shape change, but not aggregation, with an EC50 value of 9.7 nM. I-SAP binds to human platelets with the maximum binding obtained between pH 6.5 and pH 7.4. In washed human platelets, the Kd for I-SAP is 468 pM at pH 7.4 and 490 pM at pH 6.5.Formal Name: (5Z)-7-[(1S,2S,3S,5R)-3-[[(4-iodophenyl)sulfonyl]amino]-6,6-dimethylbicyclo[3.1.1]hept-2-yl]-5-heptenoic acid. CAS Number: 133538-58-6. Synonyms: Iodophenyl sulfonyl amino pinane Thromboxane A2, Iodophenyl sulfonyl amino pinane TXA2. Molecular Formula: C22H30INO4S. Formula Weight: 531.4. Purity: >98%. Formulation: (Request formulation change), A solution in ethanol. Solubility: DMF: >50 mg/ml (from Pinane TXA2), DMSO: >25 mg/ml (from Pinane TXA2), Ethanol: >100 mg/ml (from Pinane TXA2), PBS pH 7.2: >100 µg/ml (from Pinane TXA2). lambdamax: 249 nm. SMILES: CC1(C)[C@@H]2[C@H](C/C=C\CCCC(O)=O)[C@@H](N([H])S(C3=CC=C(I)C=C3)(=O)=O)C[C@H]1C2. InChi Code: InChI=1S/C22H30INO4S/c1-22(2)15-13-19(22)18(7-5-3-4-6-8-21(25)26)20(14-15)24-29(27,28)17-11-9-16(23)10-12-17/h3,5,9-12,15,18-20,24H,4,6-8,13-14H2,1-2H3,(H,25,26)/b5-3-/t15-,18+,19+,20+/m1/s1. InChi Key: SZNMERGTFJHNSM-JAWYFFTGSA-N.