GW 406381

GW 406381 is a non-steroidal anti-inflammatory drug (NSAID) and COX-2 inhibitor (IC50 = 3 nM). It is selective for COX-2 over COX-1 (IC50 = >84.2 µM). GW 406381 (5 mg/kg) reverses chronic construction injury-induced decreases in paw withdrawal thresholds in a rat model of neuropathic pain.Formal Name: 2-(4-ethoxyphenyl)-3-[4-(methylsulfonyl)phenyl]-pyrazolo[1,5-b]pyridazine. Synonyms: GW406381X. Molecular Formula: C21H19N3O3S. Formula Weight: 393.5. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: 25 mg/ml, sonicated. SMILES: O=S(C1=CC=C(C2=C3C=CC=NN3N=C2C4=CC=C(C=C4)OCC)C=C1)(C)=O. InChi Code: InChI=1S/C21H19N3O3S/c1-3-27-17-10-6-16(7-11-17)21-20(19-5-4-14-22-24(19)23-21)15-8-12-18(13-9-15)28(2,25)26/h4-14H,3H2,1-2H3. InChi Key: NXMZBNYLCVTRGB-UHFFFAOYSA-N.