D-myo-Inositol-1,3,4-triphosphate (sodium salt)

The inositol phosphates play a critical role as small, soluble second messengers in transmission of cellular signals. D-myo-Inositol-1,3,4-triphosphate (Ins(1,3,4)-P3) is one of several different inositol oligophosphate isomers implicated in signal transduction. Ins(1,3,4)-P3 acts through the inhibition of Ins(3,4,5,6)-P4 kinase activity to increase the cellular level of Ins(3,4,5,6)-P4 and thus inhibit calcium-activated chloride channels. The levels of Ins(1,3,4)-P3 are in turn regulated by the levels of cytosolic free calcium. The receptor-mediated activation of phospholipase C (PLC) can be seen as the initiating event in this cascade, since PLC generates Ins(1,4,5)-P3 which releases calcium from intracellular storage reservoirs, leading to a dramatic but transient increase in the cytosolic concentration of free calcium.Formal Name: D-myo-inositol-1,3,4-tris(dihydrogen phosphate), trisodium salt. Synonyms: Ins(1,3,4)-P3 (sodium salt), 1,3,4-IP3 (sodium salt). Molecular Formula: C6H12O15P3 . 3Na. Formula Weight: 486.0. Purity: >98%. Formulation: (Request formulation change), A lyophilized powder. Solubility: PBS pH 7.2: >50 mg/ml (from D-myo-Inositol. SMILES: O[C@H]1[C@@H](OP([O-])(O)=O)[C@H](O)[C@@H](O)[C@H](OP([O-])(O)=O)[C@H]1OP([O-])(O)=O.[Na+].[Na+].[Na+]. InChi Code: InChI=1S/C6H15O15P3.3Na/c7-1-2(8)5(20-23(13,14)15)6(21-24(16,17)18)3(9)4(1)19-22(10,11)12,,,/h1-9H,(H2,10,11,12)(H2,13,14,15)(H2,16,17,18),,,/q,3*+1/p-3/t1-,2-,3+,4?,5?,6?,,,/m1.../s1. InChi Key: ZVCVTWVBDIPWPZ-WWKACLBASA-K.