Azelaoyl PAF

Oxidized low-density lipoprotein (oxLDL) particles contain low molecular weight species which promote the differentiation of monocytes via the nuclear receptor PPARgamma. One of these substances was recently isolated and purified from oxLDL, and identified as azelaoyl PAF. Azelaoyl PAF is a potent PPARgamma agonist which competes for the thiazolidinedione binding site. Azelaoyl PAF is more potent than 15-deoxy-Delta12,14-prostaglandin J2, and equipotent with rosiglitazone as a ligand for this receptor.Formal Name: 1-O-hexadecyl-2-O-(9-carboxyoctanoyl)-sn-glyceryl-3-phosphocholine. CAS Number: 354583-69-0. Molecular Formula: C33H66NO9P. Formula Weight: 651.9. Purity: >98%. Formulation: (Request formulation change), A solution in ethanol. Solubility: DMF: 33 mg/ml, DMSO: 8 mg/ml, Ethanol: 20 mg/ml, PBS (pH 7.2): 10 mg/ml. SMILES: CCCCCCCCCCCCCCCCOC[C@@H](OC(CCCCCCCC(O)=O)=O)COP([O-])(OCC[N+](C)(C)C)=O. InChi Code: InChI=1S/C33H66NO9P/c1-5-6-7-8-9-10-11-12-13-14-15-16-20-23-27-40-29-31(30-42-44(38,39)41-28-26-34(2,3)4)43-33(37)25-22-19-17-18-21-24-32(35)36/h31H,5-30H2,1-4H3,(H-,35,36,38,39)/t31-/m1/s1. InChi Key: ZDFOCDTXDPKJKA-WJOKGBTCSA-N. Side Chain Carbon Sum: 25:0.