Lipide

Lipide sind kleine, organische Moleküle, die sich in der Regel durch ihre Hydrophobie or Amphiphilie auszeichnen. Beispiele für Lipide sind unter anderem Fette, Fettsäuren, Wachse, Triglyceride, Steroide und Phospholipide. Lipide sind Hauptbestandteil der biologischen Membranen aller Zellen. Daher wirken einige bakterielle Lipidstrukturen und Glykolipide als Pathogen-assoziiertes molekulares Muster (PAMPs) und werden durch das menschliche Immunsystem erkannt. Diverse Lipide und Lipidkomplexe bakteriellen Ursprungs werden aus diesem Grund als Immunstimulans verwendet.

Lipide sind kleine, organische Moleküle, die sich in der Regel durch ihre Hydrophobie or Amphiphilie auszeichnen. Beispiele für Lipide sind unter anderem Fette, Fettsäuren, Wachse, Triglyceride,... mehr erfahren »
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Lipide

Lipide sind kleine, organische Moleküle, die sich in der Regel durch ihre Hydrophobie or Amphiphilie auszeichnen. Beispiele für Lipide sind unter anderem Fette, Fettsäuren, Wachse, Triglyceride, Steroide und Phospholipide. Lipide sind Hauptbestandteil der biologischen Membranen aller Zellen. Daher wirken einige bakterielle Lipidstrukturen und Glykolipide als Pathogen-assoziiertes molekulares Muster (PAMPs) und werden durch das menschliche Immunsystem erkannt. Diverse Lipide und Lipidkomplexe bakteriellen Ursprungs werden aus diesem Grund als Immunstimulans verwendet.

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(±)14(15)-EET
(±)14(15)-EET

Artikelnummer: Cay50651-50

(±)14(15)-EET is a metabolite of arachidonic acid (Cay-90010, Cay-90010.1, Cay-10006607) that is formed via epoxidation of arachidonic acid by cytochrome P450. It prevents increases in leukotriene B4 (LTB4, Cay-20110), ICAM-1, and chemokine (C-C motif) ligand 1 (CCL2) induced by oxidized LDL in primary rat pulmonary...
Schlagworte: (±)14,15-EET, (±)14,15-EpETrE, (±)14(15)-epoxy-5Z,8Z,11Z-eicosatrienoic acid
Anwendung: Bioactive lipid assays
CAS 197508-62-6
MW: 320.5 D
ab 66,00 €
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Arachidonic Acid
Arachidonic Acid

Artikelnummer: Cay90010-100

Arachidonic acid is an essential fatty acid and a precursor for all prostaglandins, thromboxanes, and leukotrienes. Virtually all cellular arachidonic acid is esterified in membrane phospholipids where its presence is tightly regulated through multiple interconnected pathways. Free arachidonic acid is a transient,...
Schlagworte: AA, 5Z,8Z,11Z,14Z-eicosatetraenoic acid
Anwendung: Bioactive lipid assays
CAS 506-32-1
MW: 304.5 D
ab 39,00 €
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Prostaglandin F2alpha
Prostaglandin F2alpha

Artikelnummer: Cay16010-10

Prostaglandin F2alpha (PGF2alpha) is a widely distributed PG occurring in many species. It causes contraction of vascular, bronchial, intestinal, and myometrial smooth muscle, and also exhibits potent luteolytic activity. PGF2alpha exerts its receptor mediated physiological activity at 50-100 nM. Maximal ovine...
Schlagworte: Dinoprost, PGF2alpha, 9alpha,11alpha,15S-trihydroxy-prosta-5Z,13E-dien-1-oic acid
Anwendung: Bioactive lipid assays
CAS 551-11-1
MW: 354.5 D
ab 50,00 €
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(±)9-HODE
(±)9-HODE

Artikelnummer: Cay38400-100

(±)9-HODE is one of the two racemic monohydroxy fatty acids resulting from the non-enzymatic oxidation of linoleic acid. Approximately equal proportions of both isomers are found in mitochondrial and plasma membranes of rabbit reticulocytes. Oxidized LDL contains significant amounts of esterified 9- and 13-HpODEs...
Schlagworte: (±)-9-hydroxy-10E,12Z-octadecadienoic acid
Anwendung: Bioactive lipid studies
CAS 98524-19-7
MW: 296.5 D
ab 193,00 €
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Resolvin D1
Resolvin D1

Artikelnummer: Cay10012554-10

Resolvins are a family of potent lipid mediators derived from both eicosapentaenoic acid (EPA, Cay-90110) and docosahexaenoic acid (DHA, Cay-90310). In addition to being anti-inflammatory, resolvins promote the resolution of the inflammatory response back to a non-inflamed state. Resolvin D1 (RvD1) is produced...
Schlagworte: 17(S)-Resolvin D1, RvD1, 7S,8R,17S-trihydroxy-4Z,9E,11E,13Z,15E,19Z-docosahexaenoic acid
Anwendung: Bioactive lipid assays
CAS 872993-05-0
MW: 376.5 D
ab 205,00 €
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15-deoxy-Delta12,14-Prostaglandin J2
15-deoxy-Delta12,14-Prostaglandin J2

Artikelnummer: Cay18570-1

15-deoxy-Delta12,14-Prostaglandin J2 (15-deoxy-Delta12,14-PGJ2) is formed from PGD2 by the elimination of two molecules of water. It binds selectively to PPARgamma with an EC50 value of 2 µM in a murine chimera system. 15-deoxy-Delta12,14-PGJ2 is more potent than PGD2, Delta12-PGJ2, and PGJ2 in stimulating...
Schlagworte: 15-deoxy-Delta12,14-PGJ2, 11-oxo-prosta-5Z,9,12E,14E-tetraen-1-oic acid
Anwendung: Bioactive lipid assays
CAS 87893-55-8
MW: 316.4 D
ab 43,00 €
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8-iso Prostaglandin F2alpha
8-iso Prostaglandin F2alpha

Artikelnummer: Cay16350-1

8-iso PGF2alpha is an isoprostane produced by the non-enzymatic peroxidation of arachidonic acid in membrane phospholipids. It is present in human plasma in two distinct forms - esterified in phospholipids and as the free acid. The ratio of these two forms is approximately 2:1, with a total plasma 8-iso PGF2alpha...
Schlagworte: 15-F2t-Isoprostane, 8-epi PGF2alpha, 8-iso-15(S)-Prostaglandin F2alpha, 8-Isoprostane, iPF2alpha-III,...
Anwendung: TP receptor agonist
CAS 27415-26-5
MW: 354.5 D
ab 220,00 €
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Eicosapentaenoic Acid
Eicosapentaenoic Acid

Artikelnummer: Cay90110-50

EPA is an omega-3 fatty acid abundantly available in marine organisms. It is oxygenated by COX-1 and COX-2 at rates of about 5% and 30%, respectively, compared to arachidonic acid. EPA has been shown to offer protection against coronary heart disease, thrombosis, ischemic brain injury, scaly dermatitis, and some...
Schlagworte: EPA, Timnodonic Acid, 5Z,8Z,11Z,14Z,17Z-eicosapentaenoic acid
Anwendung: Bioactive lipid assays
CAS 10417-94-4
MW: 302.5 D
ab 50,00 €
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Arachidonic Acid-d8
Arachidonic Acid-d8

Artikelnummer: Cay390010-1

Arachidonic acid-d8 is intended for use as an internal standard for the quantification of arachidonic acid (Cay-90010) by GC- or LC-MS. Arachidonic acid is an essential fatty acid and a precursor for all prostaglandins, thromboxanes, and leukotrienes. Virtually all cellular arachidonic acid is esterified in membrane...
Schlagworte: AA-d8, 5Z,8Z,11Z,14Z-eicosatetraenoic-5,6,8,9,11,12,14,15-d8 acid
Anwendung: Standard
CAS 69254-37-1
MW: 312.5 D
ab 164,00 €
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Lipoxin A4
Lipoxin A4

Artikelnummer: Cay90410-25

Lipoxin A4 (LXA4) is a trihydroxy fatty acid containing a conjugated tetraene, produced by the metabolism of (±)15-HETE (Cay-34700) or 15-HpETE with human leukocytes. LXA4 is equipotent to leukotriene B4 (Cay-20110) in inducing superoxide generation in human neutrophils at 0.1 µM. LXA4 is associated with several...
Schlagworte: 5(S),6(R),15(S)-TriHETE, LXA4, 5S,6R,15S-trihydroxy-7E,9E,11Z,13E-eicosatetraenoic acid
Anwendung: Bioactive lipid assays
CAS 89663-86-5
MW: 352.5 D
ab 270,00 €
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Arachidonoyl Ethanolamide
Arachidonoyl Ethanolamide

Artikelnummer: Cay90050-5

Arachidonoyl ethanolamide (AEA) is the ethanolamine amide of arachidonic acid, originally isolated from porcine brain. AEA is an endogenous cannabinoid neurotransmitter that binds to both cannabinoid 1 (CB1) and CB2 receptors. AEA has Ki values ranging from 61 to 543 nM for CB1 receptors and from 279 to 1,940 nM for...
Schlagworte: AEA, Anandamide, N-(2-hydroxyethyl)-5Z,8Z,11Z,14Z-eicosatetraenamide
Anwendung: Bioactive Lipid assays
CAS 94421-68-8
MW: 347.5 D
ab 54,00 €
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Fumonisin B1
Fumonisin B1

Artikelnummer: Cay62580-1

Fumonisin B1 (FB1) is a mycotoxin that has been found in F. moniliforme. It inhibits ceramide synthase (IC50 = 0.1 µM for the rat liver enzyme). FB1 induces DNA fragmentation and apoptosis in CV-1 cells when used at concentrations of 5 and 25 µM, respectively. It is cytotoxic to primary rat hepatocytes and induces...
Schlagworte: FB1, (2R,2'R)-1,2,3-propanetricarboxylic acid,...
Anwendung: Ceramide synthase inhibitor
CAS 116355-83-0
MW: 721.8 D
ab 98,00 €
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