Lipide

Lipide sind kleine, organische Moleküle, die sich in der Regel durch ihre Hydrophobie or Amphiphilie auszeichnen. Beispiele für Lipide sind unter anderem Fette, Fettsäuren, Wachse, Triglyceride, Steroide und Phospholipide. Lipide sind Hauptbestandteil der biologischen Membranen aller Zellen. Daher wirken einige bakterielle Lipidstrukturen und Glykolipide als Pathogen-assoziiertes molekulares Muster (PAMPs) und werden durch das menschliche Immunsystem erkannt. Diverse Lipide und Lipidkomplexe bakteriellen Ursprungs werden aus diesem Grund als Immunstimulans verwendet.

Lipide sind kleine, organische Moleküle, die sich in der Regel durch ihre Hydrophobie or Amphiphilie auszeichnen. Beispiele für Lipide sind unter anderem Fette, Fettsäuren, Wachse, Triglyceride,... mehr erfahren »
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Lipide

Lipide sind kleine, organische Moleküle, die sich in der Regel durch ihre Hydrophobie or Amphiphilie auszeichnen. Beispiele für Lipide sind unter anderem Fette, Fettsäuren, Wachse, Triglyceride, Steroide und Phospholipide. Lipide sind Hauptbestandteil der biologischen Membranen aller Zellen. Daher wirken einige bakterielle Lipidstrukturen und Glykolipide als Pathogen-assoziiertes molekulares Muster (PAMPs) und werden durch das menschliche Immunsystem erkannt. Diverse Lipide und Lipidkomplexe bakteriellen Ursprungs werden aus diesem Grund als Immunstimulans verwendet.

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Prostaglandin E1
Prostaglandin E1

Artikelnummer: Cay13010-1

Prostaglandin E1 (PGE1) is a vasoactive prostaglandin and an active metabolite of dihomo-gamma-linolenic acid (DGLA, Cay-90230). It is formed from DGLA by COX-1 and COX-2. PGE1 is an agonist of the PGE2 (Cay-14010) receptor subtypes EP1, EP2, EP3, and EP4, and the IP receptor (Kis = 36, 10, 1.1, 2.1, and 33 nM,...
Schlagworte: Alprostadil, PGE1, 9-oxo-11alpha,15S-dihydroxy-prost-13E-en-1-oic acid
Anwendung: Bioactive lipid assays
CAS 745-65-3
MW: 354.5 D
ab 30,00 €
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15-keto Prostaglandin E1
15-keto Prostaglandin E1

Artikelnummer: Cay13680-1

15-keto PGE1 is the inactive metabolite of PGE1 produced by 15-hydroxy PGDH. It has greatly diminished biological activity compared to PGE1.Formal Name: (11alpha,13E)-11-hydroxy-9,15-dioxo-prost-13-en-1-oic acid. CAS Number: 22973-19-9. Synonyms: 15-keto PGE1. Molecular Formula: C20H32O5. Formula Weight: 352.5....
Schlagworte: 15-keto PGE1, 9,15-dioxo-11alpha-hydroxy-prost-13E-en-1-oic acid
Anwendung: Bioactive lipid assays
CAS 22973-19-9
MW: 352.5 D
ab 88,00 €
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Prostaglandin I2 (sodium salt)
Prostaglandin I2 (sodium salt)

Artikelnummer: Cay18220-1

Prostaglandin I2 (PGI2) is an unstable cyclooxygenase metabolite detected first in vascular endothelial cells. It elevates platelet cAMP and is a potent vasodilator and inhibitor of human platelet aggregation with an IC50 of 5 nM. PGI2 is stable in basic buffers (pH=8), but it is rapidly hydrolyzed to 6-keto...
Schlagworte: Epoprostenol, PGI2, Prostacyclin, 6,9alpha-epoxy-11alpha,15S-dihydroxy-prosta-5Z,13E-dien-1-oic acid, monosodium salt
Anwendung: Bioactive lipid assays
CAS 61849-14-7
MW: 374.5 D
ab 98,00 €
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(±)11(12)-EET
(±)11(12)-EET

Artikelnummer: Cay50511-50

(±)11(12)-EET is a fully racemic version of the R/S enantiomeric forms biosynthesized from arachidonic acid (Cay-90010) by cytochrome P450 enzymes. A higher proportion of 11(R),12(S)-EET is produced by the CYP450 isoforms CYP2C23 and CYP2C24 while CYP2B2 produces a higher proportion of 11(S),12(R)-EET. 11(12)-EET...
Schlagworte: (±)11,12-EpETrE, (±)11,(12)-epoxy-5Z,8Z,14Z-eicosatrienoic acid
Anwendung: Bioactive lipid assays
CAS 87173-81-7
MW: 320.5 D
ab 61,00 €
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Docosahexaenoic Acid
Docosahexaenoic Acid

Artikelnummer: Cay90310-50

Docosahexaenoic acid (DHA) is a long-chain omega-3 polyunsaturated fatty acid (PUFA) found in fish and algal oils. It comprises approximately 40% of total brain PUFAs and is abundant in grey matter and retinal membranes. DHA typically represents 0.52-7.5% of human total plasma fatty acids. It is produced from...
Schlagworte: Cervonic Acid, DHA, 4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoic acid
Anwendung: Bioactive lipid studies
CAS 6217-54-5
MW: 328.5 D
ab 60,00 €
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Leukotriene B4
Leukotriene B4

Artikelnummer: Cay20110-25

Leukotriene B4 (LTB4) is a dihydroxy fatty acid derived from arachidonic acid through the 5-LO pathway. It promotes a number of leukocyte functions including aggregation, stimulation of ion fluxes, enhancement of lysosomal enzyme release, superoxide anion production, chemotaxis, and chemokinesis. In subnanomolar...
Schlagworte: LTB4, 5S,12R-dihydroxy-6Z,8E,10E,14Z-eicosatetraenoic acid
Anwendung: Bioactive lipid assays
CAS 71160-24-2
MW: 336.5 D
ab 193,00 €
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(±)5(6)-EET
(±)5(6)-EET

Artikelnummer: Cay50211-50

5(6)-EET is a fully racemic version of the enantiomeric forms biosynthesized from arachidonic acid (Cay-90010) by cytochrome P450 enzymes. In solution, 5(6)-EET degrades into 5,6-DiHET and 5(6)-delta-lactone, which can be converted to 5(6)-DiHET and quantified by GC-MS. In neuroendocrine cells, such as the anterior...
Schlagworte: (±)5,6-EpETrE, (±)5,6-epoxy-8Z,11Z,14Z-eicosatrienoic acid
Anwendung: Bioactive lipid assays
CAS 87173-80-6
MW: 320.5 D
ab 61,00 €
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(±)8(9)-EET
(±)8(9)-EET

Artikelnummer: Cay50351-50

(±)8(9)-EET is a fully racemic version of the R/S enantiomeric forms biosynthesized from arachidonic acid (Cay-90010). (±)8(9)-EET is a major cytochrome P450 (CYP450) metabolite in the renal cortex. It activates PPARalpha in HEK293 cells when used at a concentration of 1 µM but inhibits NF-kappaB activity induced by...
Schlagworte: (±)8,9-EpETrE, (±)8,9-epoxy-5Z,11Z,14Z-eicosatrienoic acid
Anwendung: Bioactive lipid assays
MW: 320.5 D
ab 50,00 €
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Lipid-based Drug Delivery-Tools
Sphingosine-1-phosphate (d18:1)
Sphingosine-1-phosphate (d18:1)

Artikelnummer: Cay62570-1

Sphingosine-1-phosphate (S1P) is the product of phosphorylation of sphingosine by sphingosine kinase that is secreted from cells and acts as an agonist at S1P receptors. It increases intracellular calcium levels in TAg-Jurkat cells expressing S1P1 and Gqi5, which allows for phospholipase C stimulation by Gi...
Schlagworte: S1P (d18:1), Sphingosine-1-Phosphoric Acid, 2S-amino-4E-octadecene-1,3R-diol 1-(dihydrogen phosphate)
Anwendung: Bioactive lipid assays
CAS 26993-30-6
MW: 379.5 D
ab 100,00 €
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Prostaglandin D2
Prostaglandin D2

Artikelnummer: Cay12010-1

Prostaglandin D2 (PGD2) is the major eicosanoid product of mast cells and is released in large quantities during allergic and asthmatic anaphylaxis. Mastocytosis patients produce excessive amounts of PGD2, which causes vasodilation, flushing, hypotension, and syncopal episodes. PGD2 is also produced in the brain via...
Schlagworte: PGD2, 9alpha,15S-dihydroxy-11-oxo-prosta-5Z,13E-dien-1-oic acid
Anwendung: Bioactive lipid assays
CAS 41598-07-6
MW: 352.5 D
ab 66,00 €
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Prostaglandin E2
Prostaglandin E2

Artikelnummer: Cay14010-1

PGE2 is one of the primary COX products of arachidonic acid (Cay-90010) and one of the most widely investigated prostaglandins. Its activity influences inflammation, fertility and parturition, gastric mucosal integrity, and immune modulation. The effects of PGE2 are transduced by at least four distinct receptors...
Schlagworte: Dinoprostone, PGE2, 9-oxo-11alpha,15S-dihydroxy-prosta-5Z,13E-dien-1-oic acid
Anwendung: Bioactive lipid assays
CAS 363-24-6
MW: 352.5 D
ab 35,00 €
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U-46619
U-46619

Artikelnummer: Cay16450-1

U-46619 is a stable analog of the endoperoxide prostaglandin H2, and a TP receptor agonist. It exhibits properties similar to thromboxane A2, causing platelet shape change and aggregation, and contraction of vascular smooth muscle. Mean EC50 values for shape change in human, rat, and rabbit platelets are 4.8, 6.0,...
Schlagworte: 9,11-dideoxy-9alpha,11alpha-methanoepoxy PGF2alpha, 9,11-dideoxy-9alpha,11alpha-methanoepoxy Prostaglandin F2alpha,...
Anwendung: TP receptor agonist
CAS 56985-40-1
MW: 350.5 D
ab 130,00 €
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