9-keto Fluprostenol isopropyl ester

9-keto Fluprostenol isopropyl ester
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
Cay16782-1 1 mg -

5 - 10 Werktage*

89,00 €
Cay16782-5 5 mg -

5 - 10 Werktage*

400,00 €
Cay16782-10 10 mg -

5 - 10 Werktage*

710,00 €
 
Fluprostenol is a well-studied, potent analog of prostaglandin F2alpha (PGF2alpha) and acts... mehr
Produktinformationen "9-keto Fluprostenol isopropyl ester"
Fluprostenol is a well-studied, potent analog of prostaglandin F2alpha (PGF2alpha) and acts primarily through the FP receptor. Oxidation at C-9 of fluprostenol yields 9-keto fluprostenol. Prostaglandin esters are known to be hydrolyzed in the eye to the corresponding free acids. However, the use of prostaglandin esters as prodrugs outside the eye is relatively unexplored. 9-keto Fluprostenol is an analog of PGE2 with structural modifications intended to give it a prolonged half-life and greater potency. 9-keto Fluprostenol isopropyl ester has the potential to act as an EP agonist in prodrug form. However, no studies on the pharmacology of this compound have been published to date. In addition 9-keto fluprostenol isopropyl ester is a potential metabolite of Travoprost, which is the Alcon trade name for fluprostenol isopropyl ester. In monkey cornea, this transformation was observed as a product of NADP+-dependent 15-hydroxyprostaglandin dehydrogenase when the closely related analog Latanoprost was used as a substrate. Certain F-series prostaglandins have been shown to be converted to the corresponding E-series compounds in rabbit liver and human platelet preparations. Formal Name: (+)-9-oxo-11alpha,15R-dihydroxy-16-(3-(trifluoromethyl)phenoxy)-17,18,19,20-tetranor-prosta-5Z,13E-dien-1-oic acid, isopropyl ester. CAS Number: 1219032-18-4. Synonyms: Fluprostenol Prostaglandin E2. Molecular Formula: C26H33F3O6. Formula Weight: 498.5. Purity: >98%. Formulation: A solution in ethanol. Solubility: DMF: 30 mg/ml, DMF:PBS (1:1): 500 µg/ml, DMSO: 20 mg/ml, Ethanol: 25 mg/ml. lambdamax: 222, 277 nm. SMILES: O[C@H]1[C@H](/C=C/[C@@H](O)COC2=CC(C(F)(F)F)=CC=C2)[C@@H](C/C=C\CCCC(OC(C)C)=O)C(C1)=O. InChi Code: InChI=1S/C26H33F3O6/c1-17(2)35-25(33)11-6-4-3-5-10-21-22(24(32)15-23(21)31)13-12-19(30)16-34-20-9-7-8-18(14-20)26(27,28)29/h3,5,7-9,12-14,17,19,21-22,24,30,32H,4,6,10-11,15-16H2,1-2H3/b5-3-,13-12+/t19-,21-,22-,24-/m1/s1. InChi Key: OKXNVRDMSRTJEN-FFKVAXMCSA-N.
Schlagworte: Fluprostenol Prostaglandin E2, (+)-9-oxo-11alpha,15R-dihydroxy-16-(3-(trifluoromethyl)phenoxy)-17,18,19,20-tetranor-prosta-5Z,13E-dien-1-oic acid, isopropyl ester
Hersteller: Cayman Chemical
Hersteller-Nr: 16782

Eigenschaften

Anwendung: EP agonist
MW: 498.5 D
Formel: C26H33F3O6
Reinheit: >98%
Format: Solution

Datenbank Information

CAS : 1219032-18-4| Finde Alternativen

Handhabung & Sicherheit

Lagerung: -20°C
Versand: +20°C (International: -20°C)
Signalwort: Danger
GHS-Piktogramme:
H-Sätze: H225, H360
P-Sätze: P201, P202, P210, P233, P240, P241, P242, P243, P280, P303+361+353, P308+313, P370+378, P403+235, P405, P501
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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