8-iso Prostaglandin A2

8-iso Prostaglandin A2 (8-iso PGA2) is an isoprostane. It is produced by the non-enzymatic oxidation of arachidonic acid (Cay-90010, Cay-90010.1, Cay-10006607). 8-iso PGA2 (100 µM) induces calcium influx in HEK293 cells expressing human transient receptor potential ankyrin 1 (TRPA1) and isolated mouse trigeminal neurons. It potentiates glutamate-induced cytotoxicity and decreases glutathione (GSH) levels in HT22 hippocampal cells when used at concentrations of 1 and 30 µM, respectively. 8-iso PGA2 (10 µM) inhibits VEGF-induced migration and tube formation of human coronary artery endothelial cells, an effect that can be reversed by the TP receptor antagonist SQ 29,548 (Cay-19025).Formal Name: (8beta)-15S-hydroxy-9-oxo-prosta-5Z,10,13E-trien-1-oic acid. CAS Number: 474391-66-7. Synonyms: A2 Isoprostane, 15-A2t-IsoP, 15-A2t-Isoprostane, 8-epi PGA2, 8-iso PGA2. Molecular Formula: C20H30O4. Formula Weight: 334.5. Purity: >98%. Limit of Detection: . Formulation: (Request formulation change), A solution in methyl acetate. Solubility: DMF: >75 mg/ml, DMSO: >50 mg/ml, Ethanol: >100 mg/ml, PBS pH 7.2: >2.4 mg/ml. lambdamax: 217 nm. SMILES: O=C1[C@@H](C/C=C\CCCC(O)=O)[C@@H](/C=C/[C@@H](O)CCCCC)C=C1. InChi Code: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12-18,21H,2-3,5-6,8-11H2,1H3,(H,23,24)/b7-4-,14-12+/t16-,17-,18-/m0/s1. InChi Key: MYHXHCUNDDAEOZ-UKUWKSPLSA-N.