8-iso Misoprostol

Misoprostol is a widely sold analog of prostaglandin E1 (PGE1) which has potent but relatively non-selective agonist activity with respect to the prostanoid EP receptor subgroup. Misoprostol has been used therapeutically for many years in humans for the treatment of gastric ulcer disease under the Searle tradename Cytotec. 8-iso Misoprostol is one of several impurities which are possible in the production of bulk commercial preparations of misoprostol, and is somewhat difficult to distinguish from other impurities such as 11beta-misoprostol. The pharmacology and EP receptor binding affinity for 8-iso misoprostol has not been published.Formal Name: 9-oxo-11alpha,16-dihydroxy-16-methyl-(8beta)-prost-13E-en-1-oic acid, methyl ester. Molecular Formula: C22H38O5. Formula Weight: 382.5. Purity: >98%. Formulation: (Request formulation change), A solution in ethanol. Solubility: DMF: 100 mg/ml, DMSO: 50 mg/ml, Ethanol: 50 mg/ml, PBS (pH 7.2): 1 mg/ml. SMILES: CCCCC(C)(O)C/C=C/[C@H]1C(O)CC(=O)[C@H]1CCCCCCC(=O)OC. InChi Code: InChI=1S/C22H38O5/c1-4-5-14-22(2,26)15-10-12-18-17(19(23)16-20(18)24)11-8-6-7-9-13-21(25)27-3/h10,12,17-18,20,24,26H,4-9,11,13-16H2,1-3H3/b12-10+/t17-,18+,20+,22?/m0/s1. InChi Key: OJLOPKGSLYJEMD-PJCYZMLPSA-N.