8-iso-15-keto Prostaglandin F2alpha

8-iso-15-keto Prostaglandin F2alpha (8-iso-15-keto PGF2alpha) is a metabolite of the isoprostane 8-iso PGF2alpha in rabbits, monkeys, and humans. 8-isoprostane (8-iso PGF2alpha) is a prostaglandin-like product of non-specific lipid peroxidation. In both humans and monkeys, exogenously infused 8-iso PGF2alpha is converted primarily to metabolites having 2 or 4 carbon atoms removed from the top side chain by beta-oxidation. A similar pattern is observed when tritiated 8-iso PGF2alpha is infused into rabbits. Early in the infusion (within 1-2 minutes) 8-iso -15-keto PGF2alpha was a major component of the metabolite profile, which was comprised mostly of unmetabolized 8-iso PGF2alpha. 8-iso -15-keto PGF2alpha is a vasoconstrictor when tested on the rat isolated thoracic aorta, acting via the TP (thromboxane) receptor.Formal Name: 9alpha,11alpha-dihydroxy-15-oxo-(8beta)-prosta-5Z,13E-dien-1-oic acid. CAS Number: 191919-01-4. Synonyms: 8-epi-15-keto PGF2alpha, 8-iso-15-keto PGF2alpha. Molecular Formula: C20H32O5. Formula Weight: 352.5. Purity: >95%. Formulation: (Request formulation change), A solution in methyl acetate. Solubility: 10 mM Na2CO3: >6.5 mg/ml, DMF: >100 mg/ml, DMSO: >100 mg/ml, Ethanol: >100 mg/ml, PBS pH 7.2: >10 mg/ml. lambdamax: 230 nm. SMILES: O[C@@H]1[C@@H](C/C=C\CCCC(O)=O)[C@@H](/C=C/C(CCCCC)=O)[C@H](O)C1. InChi Code: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,16-19,22-23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/b7-4-,13-12+/t16-,17+,18-,19+/m0/s1. InChi Key: LOLJEILMPWPILA-RLXHZABYSA-N.