17-phenyl trinor Prostaglandin F2alpha isopropyl ester

17-phenyl trinor Prostaglandin F2alpha isopropyl ester
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
Cay16824-1 1 mg -

5 - 10 Werktage*

74,00 €
Cay16824-5 5 mg -

5 - 10 Werktage*

333,00 €
Cay16824-10 10 mg -

5 - 10 Werktage*

590,00 €
 
17-phenyl trinor PGF2alpha N-ethyl amide is an F-series prostaglandin analog which has been... mehr
Produktinformationen "17-phenyl trinor Prostaglandin F2alpha isopropyl ester"
17-phenyl trinor PGF2alpha N-ethyl amide is an F-series prostaglandin analog which has been approved for use as an ocular hypotensive drug, sold under the Allergan trade name Bimatoprost. The N-ethyl amide prostaglandin prodrugs are converted to the active free acid more slowly than the analogous prostaglandin ester prodrugs such as latanoprost. This product is the isopropyl ester of the free acid prostaglandin which corresponds to Bimatoprost. The free acid, 17-phenyl trinor PGF2alpha, is a potent FP receptor agonist. In human and animal models of glaucoma, FP receptor agonist activity corresponds very closely with intraocular hypotensive activity. The 17-phenyl trinor PGF2alpha isopropyl ester derivative was examined for IOP-lowering activity during the development of latanoprost. At the dose of 3 µg/eye in the monkey, 17-phenyl trinor PGF2alpha isopropyl ester was the most potent analog tested in reducing IOP, lowering the IOP 1.3 mm Hg below the level achieved by latanoprost. However, this derivative was also significantly more irritating to the eye than latanoprost.
Schlagworte: 17-phenyl trinor PGF2alpha isopropyl ester, 17-phenyl trinor PGF2alpha-iPr, Bimatoprost isopropyl ester, 9alpha,11alpha,15S-trihydroxy-17-phenyl-18,19,20-trinor-prosta-5Z,13E-dien-1-oic acid, isopropyl ester
Hersteller: Cayman Chemical
Hersteller-Nr: 16824

Eigenschaften

Anwendung: FP receptor agonist
MW: 430.6 D
Formel: C26H38O5
Reinheit: >98%
Format: Solution

Datenbank Information

CAS : 130209-76-6| Finde Alternativen

Handhabung & Sicherheit

Lagerung: -20°C
Versand: +20°C (International: -20°C)
Signalwort: Danger
GHS-Piktogramme:
H-Sätze: H225, H302, H315, H319, H335, H336, H360, H372
P-Sätze: P201, P202, P210, P240, P241, P242, P243, P260, P261, P264, P270, P271, P280, P312, P314, P321, P330, P301+P310, P302+P352, P303+P361+P353, P304+P340, P305+P351+P338, P308+P313, P332+P313, P337+P313, P362+P364, P370+P378, P405, P403+P233, P403+P235, P501
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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