(±)17-HETE

Electrolyte and fluid transport in the kidney are regulated in part by arachidonic acid and its metabolites. (±)17-HETE is the racemic version of a cytochrome P450 (CYP450) metabolite of arachidonic acid that has stereospecific effects on sodium transport in the kidney. At a concentration of 2 µM the (S)-enantiomer of 17-HETE inhibits proximal tubule ATPase activity by as much as 70%, whereas the (R)-isomer is inactive.Formal Name: (±)17-hydroxy-5Z,8Z,11Z,14Z-eicosatetraenoic acid. CAS Number: 128914-47-6. Synonyms: (±)-Hydroxyeicosatetraenoic Acid. Molecular Formula: C20H32O3. Formula Weight: 320.5. Purity: >98%. Formulation: (Request formulation change), A solution in ethanol. Solubility: 0.1 m Na2CO3: 2 mg/ml, DMF: Miscible, DMSO: Miscible, Ethanol: Miscible, PBS (pH 7.2): 0.8 mg/ml. SMILES: CCCC(O)C/C=C\C/C=C\C/C=C\C/C=C\CCCC(=O)O. InChi Code: InChI=1S/C20H32O3/c1-2-16-19(21)17-14-12-10-8-6-4-3-5-7-9-11-13-15-18-20(22)23/h3,5-6,8-9,11-12,14,19,21H,2,4,7,10,13,15-18H2,1H3,(H,22,23)/b5-3-,8-6-,11-9-,14-12-. InChi Key: OPPIPPRXLIDJKN-JPURVOHMSA-N.