15(S)-Fluprostenol isopropyl ester

15(S)-Fluprostenol isopropyl ester
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
Cay16788-1 1 mg -

6 - 10 Werktage*

114,00 €
Cay16788-5 5 mg -

6 - 10 Werktage*

501,00 €
Cay16788-10 10 mg -

6 - 10 Werktage*

885,00 €
 
15(S)-Fluprostenol isopropyl ester (15(S)-Flu-Ipr) is the unnatural C-15 epimer of Travoprost.... mehr
Produktinformationen "15(S)-Fluprostenol isopropyl ester"
15(S)-Fluprostenol isopropyl ester (15(S)-Flu-Ipr) is the unnatural C-15 epimer of Travoprost. Travoprost is the Alcon trade name for fluprostenol isopropyl ester, (Flu-Ipr) an F-series prostaglandin analog which has been approved for use as an ocular hypotensive drug. Flu-Ipr is a prodrug which is converted by esterase enzymatic activity in the cornea to yield the corresponding free acid. The free acid, fluprostenol, is a potent FP receptor agonist. In human and animal models of glaucoma, FP receptor agonist activity corresponds very closely with intraocular hypotensive activity. Although data is currently not available for the activity of 15(S)-Flu-Ipr, inversion of the stereochemistry at the 15 position of ocular hypotensive prostaglandins generally lowers the potency approximately 100 fold.Formal Name: (5Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(1E,3S)-3-hydroxy-4-[3-(trifluoromethyl)phenoxy]-1-buten-1-yl]cyclopentyl]-5-heptenoic acid, 1-methylethyl ester. CAS Number: 1420791-14-5. Synonyms: 15(S)-Flu-Ipr. Molecular Formula: C26H35F3O6. Formula Weight: 500.6. Purity: >98%. Formulation: (Request formulation change), A solution in ethanol. Solubility: DMF: 15 mg/ml, DMSO: 12 mg/ml, Ethanol: 30 mg/ml, Ethanol:PBS (pH 7.2) (1:1): 1 mg/ml. lambdamax: 222, 280 nm. SMILES: O[C@@H]1[C@H](C/C=C\CCCC(OC(C)C)=O)[C@@H](/C=C/[C@H](O)COC2=CC=CC(C(F)(F)F)=C2)[C@H](O)C1. InChi Code: InChI=1S/C26H35F3O6/c1-17(2)35-25(33)11-6-4-3-5-10-21-22(24(32)15-23(21)31)13-12-19(30)16-34-20-9-7-8-18(14-20)26(27,28)29/h3,5,7-9,12-14,17,19,21-24,30-32H,4,6,10-11,15-16H2,1-2H3/b5-3-,13-12+/t19-,21+,22+,23-,24+/m0/s1. InChi Key: MKPLKVHSHYCHOC-AURHPGDUSA-N.
Schlagworte: 15(S)-Flu-Ipr, 9alpha,11alpha,15S-trihydroxy-16-(3-(trifluoromethyl)phenoxy)-17,18,19,20-tetranor-prosta-5Z,13E-dien-1-oic acid, isopropyl ester
Hersteller: Cayman Chemical
Hersteller-Nr: 16788

Eigenschaften

Anwendung: Bioactive lipid assays
MW: 500.6 D
Formel: C26H35F3O6
Reinheit: >98%
Format: Solution

Datenbank Information

CAS : 1420791-14-5| Passende Produkte

Handhabung & Sicherheit

Lagerung: -20°C
Versand: +20°C (International: -20°C)
Signalwort: Danger
GHS-Piktogramme:
H-Sätze: H225, H319
P-Sätze: P210, P233, P240, P241, P242, P243, P264, P280, P303+361+353, P305+351+338, P337+313, P370+378, P403+235, P501
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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