14,15-Leukotriene C4

14,15-Leukotriene C4
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
Cay10011360-25 25 µg -

5 - 10 Werktage*

128,00 €
Cay10011360-50 50 µg -

5 - 10 Werktage*

243,00 €
Cay10011360-100 100 µg -

5 - 10 Werktage*

459,00 €
 
Leukotrienes (LTs) are a group of acute inflammatory mediators derived from arachidonic acid in... mehr
Produktinformationen "14,15-Leukotriene C4"
Leukotrienes (LTs) are a group of acute inflammatory mediators derived from arachidonic acid in leukocytes. The majority of these metabolites are formed through the 5-lipoxygenase (5-LO) pathway. 14,15-LTC4 is a member of an alternate class of LTs synthesized by a pathway involving the dual actions of 15- and 12-LOs on arachidonic acid via 15-HpETE and 14,15-LTA4 intermediates. 14,15-LTC4 is classified as an eoxin, because it is formed mostly by eosinophils. However, mast cells and nasal polyps can synthesize 14,15-LTC4 as well. Little is known about the physiological actions of 14,15-LTC4. It has weak contractile activity on both guinea pig ileum and pulmonary parenchyma in contrast to the effects of 5-LO-derived LTs. However, in an in vitro permeability assay, 14,15-LTC4 can increase vascular permeability of human endothelial cell monolayers, with similar potency to that of 5-LO-derived LTs resulting in plasma leakage - a hallmark of inflammation.
Schlagworte: 14,15-LTC4, Eoxin C4, EXC4, 15S-hydroxy-14R-(S-glutathionyl)-5Z,8Z,10E,12E-eicosatetraenoic acid
Hersteller: Cayman Chemical
Hersteller-Nr: 10011360

Eigenschaften

Anwendung: Bioactive lipid assays
MW: 625.8 D
Formel: C30H47N3O9S
Reinheit: >95%
Format: Solution

Datenbank Information

CAS : 75290-60-7| Finde Alternativen

Handhabung & Sicherheit

Lagerung: -80°C
Versand: -20°C (International: -80°C)
Signalwort: Danger
GHS-Piktogramme:
H-Sätze: H225, H301, H311, H331, H370
P-Sätze: P210, P240, P241, P242, P243, P260, P261, P264, P270, P271, P280, P312, P321, P330, P301+P310, P302+P352, P303+P361+P353, P304+P340, P308+P311, P361+P364, P370+P378, P405, P403+P233, P403+P235, P501
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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