12-epi Leukotriene B4

12-epi Leukotriene B4
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
Cay20135-25 25 µg -

5 - 10 Werktage*

168,00 €
Cay20135-50 50 µg -

5 - 10 Werktage*

319,00 €
Cay20135-100 100 µg -

5 - 10 Werktage*

603,00 €
 
Leukotriene B4 (LTB4) compounds are produced by both enzymatic and non-enzymatic processes. The... mehr
Produktinformationen "12-epi Leukotriene B4"
Leukotriene B4 (LTB4) compounds are produced by both enzymatic and non-enzymatic processes. The products of enzymatic origin, via Leukotriene A4 (LTA4) hydrolase, are stereospecifically 12(R). Non-enzymatic hydrolysis products are 50:50 mixtures at C-12, but are almost exclusively trans at C-6. Thus, the non-enzymatic hydrolysis product of LTA4 is 6-trans-12-epi LTB4. 12-epi LTB4 is an isomer which would not be expected to occur in either non-enzymatic hydrolysis products, or in the enzymatic products of LTA4 hydrolase. Compared to LTB4, 12-epi LTB4 has significantly reduced activity for the LTB4 receptor on human neutrophils (IC50 of 7.5 mM), and on guinea pig lung membranes with a (Ki of 4.7 mM). 12-epi LTB4 is an weak agonist at both the recombinant human BLT1 and BLT2 receptors, requiring approximately 10 mM for full activation of the receptor. Formal Name: 5S,12S-dihydroxy-6Z,8E,10E,14Z-eicosatetraenoic acid. CAS Number: 83709-73-3. Synonyms: 12-epi LTB4. Molecular Formula: C20H32O4. Formula Weight: 336.5. Purity: >97%. Formulation: A solution in ethanol. Solubility: DMF: >50 mg/ml (per Rao Maddipati), DMSO: >50 mg/ml (per Rao Maddipati), Ethanol: >50 mg/ml (per Rao Maddipati), PBS pH 7.2: >1 mg/ml (from 13(S)-HODE). lambdamax: 270 nm. SMILES: CCCCC/C=C\C[C@H](O)/C=C/C=C/C=C\[C@@H](O)CCCC(O)=O. InChi Code: InChI=1S/C20H32O4/c1-2-3-4-5-6-9-13-18(21)14-10-7-8-11-15-19(22)16-12-17-20(23)24/h6-11,14-15,18-19,21-22H,2-5,12-13,16-17H2,1H3,(H,23,24)/b8-7+,9-6-,14-10+,15-11-/t18-,19+/m0/s1. InChi Key: VNYSSYRCGWBHLG-CBBLYLIKSA-N.
Schlagworte: 12-epi LTB4, 5S,12S-dihydroxy-6Z,8E,10E,14Z-eicosatetraenoic acid
Hersteller: Cayman Chemical
Hersteller-Nr: 20135

Eigenschaften

Anwendung: BLT receptor agonist
MW: 336.5 D
Formel: C20H32O4
Reinheit: >97%
Format: Solution

Datenbank Information

CAS : 83709-73-3| Finde Alternativen

Handhabung & Sicherheit

Lagerung: -20°C
Versand: -20°C (International: -20°C)
Signalwort: Danger
GHS-Piktogramme:
H-Sätze: H225
P-Sätze: P210, P233, P240, P241, P242, P243, P280, P303+361+353, P370+378, P403+235, P501
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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