12-epi Leukotriene B3

12-epi Leukotriene B3
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
Cay20134-25 25 µg -

6 - 10 Werktage*

168,00 €
Cay20134-50 50 µg -

6 - 10 Werktage*

319,00 €
Cay20134-100 100 µg -

6 - 10 Werktage*

603,00 €
12-epi LTB3 is an LTB isomer that would not be formed either by known enzymatic or non-enzymatic... mehr
Produktinformationen "12-epi Leukotriene B3"
12-epi LTB3 is an LTB isomer that would not be formed either by known enzymatic or non-enzymatic processes. The conversion of LTA into different isomers of LTB is complex, and has generated confusion in the past. The enzymatic hydrolysis of LTA leads to LTB, which is the corresponding 5(S),12(R)-dihydroxy acid containing a 6(Z),8(E),10(E) conjugated triene. Non-enzymatic hydrolysis of LTA produces none of this material, but instead produces both the 12(S) and the 12(R) isomers of LTB in which the triene component now contains a 6-trans double bond. 12-epi (or 12(S)) LTB isomers which contain the natural 6-cis olefin are not produced either by enzymatic or by non-enzymatic processes. Further, 3-series LTs (derived from Mead acid) are only seen in essential fatty acid deficiency. Mead acid is a good substrate for 5-lipoxygenase, leading to LTA3. Enzymatic conversion of LTA3 to LTB3 is very low because LTA3 is actually an inhibitor of LTA hydrolase. Non-enzymatic hydrolysis of LTA3 leads to 6-trans-12-epi LTB3, and to 6-trans LTB3. The biological activity of 12-epi LTB3 has not been explored. Formal Name: 5S,12S-dihydroxy-6Z,8E,10E-eicosatrienoic acid. Synonyms: 12-epi LTB3. Molecular Formula: C20H34O4. Formula Weight: 338.5. Purity: >97%. Formulation: A solution in ethanol. Solubility: DMF: Miscible, DMSO: Miscible, Ethanol: Miscible, PBS (pH 7.2): 1 mg/ml (from 13-HODE). lambdamax: 270 nm. SMILES: CCCCCCCC[C@H](O)/C=C/C=C/C=C\[C@@H](O)CCCC(O)=O. InChi Code: InChI=1S/C20H34O4/c1-2-3-4-5-6-9-13-18(21)14-10-7-8-11-15-19(22)16-12-17-20(23)24/h7-8,10-11,14-15,18-19,21-22H,2-6,9,12-13,16-17H2,1H3,(H,23,24)/b8-7+,14-10+,15-11-/t18-,19+/m0/s1. InChi Key: NGTXCORNXNELNU-OUZMKVEGSA-N.
Schlagworte: 12-epi LTB3, 5S,12S-dihydroxy-6Z,8E,10E-eicosatrienoic acid
Hersteller: Cayman Chemical
Hersteller-Nr: 20134


Anwendung: Bioactive lipid assays
MW: 338.5 D
Formel: C20H34O4
Reinheit: >97%
Format: Solution

Datenbank Information

Handhabung & Sicherheit

Lagerung: -20°C
Versand: -20°C (International: -20°C)
Signalwort: Danger
H-Sätze: H225
P-Sätze: P210, P233, P240, P241, P242, P243, P280, P303+361+353, P370+378, P403+235, P501
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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