1-Stearoyl-2-Arachidonoyl-sn-Glycerol-d8

1-Stearoyl-2-Arachidonoyl-sn-Glycerol-d8
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
Cay10009872-100 100 µg -

6 - 10 Werktage*

57,00 €
Cay10009872-500 500 µg -

6 - 10 Werktage*

254,00 €
Cay10009872-1 1 mg -

6 - 10 Werktage*

450,00 €
 
1-Stearoyl-2-arachidonoyl-d8-sn-glycerol (SAG-d8) is intended for use as an internal standard for... mehr
Produktinformationen "1-Stearoyl-2-Arachidonoyl-sn-Glycerol-d8"
1-Stearoyl-2-arachidonoyl-d8-sn-glycerol (SAG-d8) is intended for use as an internal standard for the quantification of SAG (Cay-10008650) by GC- or LC-MS. Many protein kinase C (PKC) isoforms require activation via second messengers including Ca2+, diacylglycerol (DAG), and/or a phospholipid in order to phosphorylate target proteins, initiating a variety of important signaling cascades. 1-Stearoyl-2-arachidonoyl-sn-glycerol (SAG) is a DAG that contains the omega-6 polyunsaturated fatty acid arachidonic acid in the sn-2 position and stearic acid in the sn-1 position of the glycerol backbone. It can potently activate PKCalpha, epsilon, and delta at nM concentrations. Independent of PKC signaling, SAG competitively binds to the Ras activator RasGRP with a Ki value of 4.49 µM in Jurkat T cells. Formal Name: 1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-5,6,8,9,11,12,14,15-d8-sn-glycerol. Synonyms: SAG-d8. Molecular Formula: C41H64D8O5. Formula Weight: 653.1. Purity: >99% deuterated forms (d1-d8). Formulation: A solution in acetonitrile. Solubility: Ethanol: 30 mg/ml, Ethanol:PBS (pH 7.2) (1:2): 0.3 mg/ml. SMILES: CCCCCCCCCCCCCCCCCC(=O)OC[C@H](CO)OC(=O)CCC/C=C\C/C=C\C/C=C\C/C=C\CCCCC. InChi Code: InChI=1S/C41H72O5/c1-3-5-7-9-11-13-15-17-19-20-22-24-26-28-30-32-34-36-41(44)46-39(37-42)38-45-40(43)35-33-31-29-27-25-23-21-18-16-14-12-10-8-6-4-2/h11,13,17,19,22,24,28,30,39,42H,3-10,12,14-16,18,20-21,23,25-27,29,31-38H2,1-2H3/b13-11-,19-17-,24-22-. InChi Key: NSXLMTYRMFVYNT-YVJRVKRGSA-N. Side Chain Carbon Sum: 38:4.
Schlagworte: SAG-d8, 1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-5,6,8,9,11,12,14,15-d8-sn-glycerol
Hersteller: Cayman Chemical
Hersteller-Nr: 10009872

Eigenschaften

Anwendung: Standard
MW: 653.1 D
Formel: C41H64D8O5
Reinheit: >99% deuterated forms (d1-d8)
Format: Solution

Datenbank Information

Handhabung & Sicherheit

Lagerung: -80°C
Versand: -20°C (International: -80°C)
Signalwort: Danger
GHS-Piktogramme:
H-Sätze: H225, H302+312+332, H319
P-Sätze: , P210, P233, P240, P241, P242, P243, P264, P280, P303+361+353, P305+351+338, P337+313, P370+378, P403+235, P501
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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