VUF8430 (hydrobromide)

VUF8430 is a histamine H4 receptor agonist (Ki = 31.6 nM). It is selective for histamine H4 over H1 and H3 receptors in radioligand binding assays (Kis = >1 and 1 µM, respectively) and is less active in isolated guinea pig atria, which endogenously expresses high levels of H2 receptors (pD2 = 3.8). VUF8430 inhibits forskolin-induced, cAMP-mediated increases in beta-galactosidase activity (EC50 = 50.1 nM). In vivo, VUF8430 (30 mg/kg) enhances HCl-induced formation of gastric lesions in rats. It also reduces mechanical and thermal allodynia in a mouse model of peripheral neuropathy induced by spared nerve injury (SNI).Formal Name: carbamimidothioic acid, 2-[(aminoiminomethyl)amino]ethyl ester, dihydrobromide. CAS Number: 100130-32-3. Molecular Formula: C4H11N5S . 2HBr. Formula Weight: 323.1. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMSO: 100 mM, Water: 100 mM. SMILES: NC(SCCNC(N)=N)=N.Br.Br. InChi Code: InChI=1S/C4H11N5S.2BrH/c5-3(6)9-1-2-10-4(7)8,,/h1-2H2,(H3,7,8)(H4,5,6,9),2*1H. InChi Key: GPWJSTKHQMIXCA-UHFFFAOYSA-N.