TUG-891

TUG-891 is an agonist of free fatty acid receptor 4 (FFAR4/GPR120, EC50s = 0.0436 and 0.0169 µM for the human and mouse receptors, respectively). It is selective for FFAR4 over FFAR1/GPR40 (EC50 = 64.5 µM for the human receptor) and is inactive against FFAR2/GPR43 and FFAR3/GPR41. TUG-891 (1 µM) inhibits lysophosphatidic acid- or EGF-induced proliferation and migration of DU145 and PC3 prostate cancer cells. It stimulates glucagon-like peptide 1 (GLP-1) release in STC-1 enteroendrocrine cells and glucose uptake in 3T3-L1 adipocytes, as well as inhibits LPS-induced TNF-alpha release in RAW 264.7 macrophages when used at a concentration of 10 µM. TUG-891 (20 mg/kg) reduces sleep fragmentation-induced increases in food consumption and epididymal fat mass in mice.Formal Name: 4-[(4-fluoro-4'-methyl[1,1'-biphenyl]-2-yl)methoxy]-benzenepropanoic acid. CAS Number: 1374516-07-0. Molecular Formula: C23H21FO3. Formula Weight: 364.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 1 mg/ml, DMSO: 10 mg/ml, DMSO:PBS (pH 7.2) (1:5): 0.1 mg/ml, Ethanol: 1 mg/ml. SMILES: CC1=CC=C(C2=CC=C(F)C=C2COC3=CC=C(CCC(O)=O)C=C3)C=C1. InChi Code: InChI=1S/C23H21FO3/c1-16-2-7-18(8-3-16)22-12-9-20(24)14-19(22)15-27-21-10-4-17(5-11-21)6-13-23(25)26/h2-5,7-12,14H,6,13,15H2,1H3,(H,25,26). InChi Key: LPGBXHWIQNZEJB-UHFFFAOYSA-N.