Spike(SARS-CoV-2) Pseudotyped Lentivirus (Luc-eGFP Dual Reporter)

Spike(SARS-CoV-2) Pseudotyped Lentivirus (Luc-eGFP Dual Reporter)
Spike(SARS-CoV-2) Pseudotyped Lentivirus (Luc-eGFP Dual Reporter)
Spike(SARS-CoV-2) Pseudotyped Lentivirus (Luc-eGFP Dual Reporter)
     
COVID-19 Forschung
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
BPS-79982-1 100 µl - -

3 - 15 Werktage*

1.568,00 €
BPS-79982-2 1000 µl (500 µl x 2) - -

3 - 15 Werktage*

10.381,00 €
 
The pandemic coronavirus disease 2019 (COVID-19) is caused by Severe Acute Respiratory Syndrome... mehr
Produktinformationen "Spike(SARS-CoV-2) Pseudotyped Lentivirus (Luc-eGFP Dual Reporter)"
The pandemic coronavirus disease 2019 (COVID-19) is caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). As the first step of viral replication, the virus attaches to the host cell surface before entering the cell. The viral Spike protein recognizes and attaches to the Angiotensin-Converting Enzyme 2 (ACE2) receptor found on the surface of type I and II pneumocytes, endothelial cells, and ciliated bronchial epithelial cells. Drugs targeting the interaction between the Spike protein of SARS-CoV-2 and ACE2 may offer protection against the viral infection. The SARS-CoV-2 Spike Pseudotyped Lentivirus (Luc-eGFP dual reporter) were produced by replacing the VSV-G fusion glycoprotein with SARS-CoV-2 Spike protein (Genbank Accession #QHD43416.1) as a surrogate viral envelope protein.. These pseudovirions also contain a firefly luciferase and eGFP cassette (Luc-P2A-eGFP) driven by a CMV promoter. The luciferase and eGFP are coexpressed under the CMV promoter in the transduced cells. Therefore, the Spike-mediated entry into the target cell can be conveniently measured via luciferase reporter activity or eGFP expression. The SARS-CoV-2 Spike pseudotyped lentivirus can be used in a cellular assay to measure the activity of neutralizing antibody against SARS-CoV-2
Schlagworte: 2,
Hersteller: BPS Bioscience
Hersteller-Nr: 79982

Eigenschaften

Anwendung: Viral transduction mechanism studies, SARS-CoV-2 Spike, ACE2 binding neutralizing antibody screening
Spezies-Reaktivität: SARS-CoV-2

Datenbank Information

UniProt ID : P0DTC2 | Passende Produkte
Gene ID GeneID 43740568 | Passende Produkte

Handhabung & Sicherheit

Lagerung: -80°C
Versand: -80°C (International: °C)
Achtung
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