SB431542, Free Base

SB431542, Free Base
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
LC-S-7800_5mg 5 mg -

3 - 15 Werktage*

82,00 €
LC-S-7800_10mg 10 mg -

3 - 15 Werktage*

96,00 €
LC-S-7800_25mg 25 mg -

3 - 15 Werktage*

145,00 €
LC-S-7800_50mg 50 mg -

3 - 15 Werktage*

232,00 €
LC-S-7800_100mg 100 mg -

3 - 15 Werktage*

385,00 €
LC-S-7800_200mg 200 mg -

3 - 15 Werktage*

660,00 €
LC-S-7800_500mg 500 mg -

3 - 15 Werktage*

1.040,00 €
LC-S-7800_1g 1 g -

3 - 15 Werktage*

1.662,00 €
 
Soluble in DMSO. SB-431542 selectively inhibited Smad3 phosphorylation, with an IC50 of 94 nM.... mehr
Produktinformationen "SB431542, Free Base"
Soluble in DMSO. SB-431542 selectively inhibited Smad3 phosphorylation, with an IC50 of 94 nM. It also blocked TGF-beta1-induced nuclear Smad3 localization. Laping N.J., et al. 'Inhibition of transforming growth factor (TGF)-beta1-induced extracellular matrix with a novel inhibitor of the TGF-beta type I receptor kinase activity: SB-431542.' Mol. Pharmacol. 62: 58-64 (2002). SB-431542 is a potent inhibitor of activin receptor-like kinase (ALK)5 (the TGF-beta type I receptor). It also inhibits the activin type I receptor ALK4 and the nodal type I receptor ALK7. It has no major effect on the other ALK family members that recognize bone morphogenetic proteins (BMPs). Inman G.J., et al. 'SB-431542 is a potent and specific inhibitor of transforming growth factor-beta superfamily type I activin receptor-like kinase (ALK) receptors ALK4, ALK5, and ALK7.' Mol. Pharmacol. 62: 65-74 (2002). SB-431542 is a specific inhibitor of TGF-beta receptor kinase. It inhibits TGF-beta-induced transcription, gene expression and tumor-promoting effects. Interestingly, SB-431542 promoted anchorage independent growth of cells which were growth-inhibited by TGF-beta, whereas it inhibited colony formation by cells which were growth-promoted by TGF-beta. Halder S.K., et al. 'A specific inhibitor of TGF-beta receptor kinase, SB-431542, as a potent antitumor agent for human cancers.' Neoplasia. 7: 509-521 (2005).
Schlagworte: SB 431542, 4-(5-Benzol[1,3]dioxol-5-yl-4-pyrldin-2-yl-1H-imidazol-2-yl)-benzamide hydrate, 4-[4-(1,3-Benzodioxol-5-yl)-5-(2-pyridinyl)-1H-imidazol-2-yl]-benzamide hydrate, 4-[4-(3,4-Methylenedioxyphenyl)-5-(2-pyridyl)-1H-imidazol-2-yl]-benzamide hydrate
Hersteller: LC Laboratories
Hersteller-Nr: S-7800

Eigenschaften

Anwendung: Smad3 phosphorylation inhibitor, TGFBR1/ALK4/ALK7 kinase inhibitor
MW: 384.39 D
Formel: C22H16N4O3
Reinheit: >99%
Format: Solid

Datenbank Information

CAS : 301836-41-9| Finde Alternativen
KEGG ID : K04674 | Finde Alternativen

Handhabung & Sicherheit

Lagerung: -20°C
Versand: +20°C (International: +20°C)
Signalwort: Warning
GHS-Piktogramme:
H-Sätze: H302+H312+H332
P-Sätze: P262
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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