SB-431542 (hydrate)

SB-431542 is a potent and selective inhibitor of the TGF-beta1 receptor ALK5 (IC50 = 94 nM). It is a less potent antagonist of ALK4 (IC50 = 140 nM) and ALK7. It does not affect the BMP receptors ALK2, ALK3, ALK6, or a panel of other kinases tested. SB-431542 specifically blocks Smad signaling, reducing gene expression relevant to fibrosis and cancer. Through its effects on ALK/Smad signaling, SB-431542 suppresses renewal in embryonic and induced pluripotent stem cells and promotes their differentiation.Formal Name: 4-[4-(1,3-benzodioxol-5-yl)-5-(2-pyridinyl)-1H-imidazol-2-yl]-benzamide, hydrate. Molecular Formula: C22H16N4O3 . XH2O. Formula Weight: 384.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 20 mg/ml, DMSO: 20 mg/ml, DMSO:PBS(pH7.2) (1:1): 0.5 mg/ml, Ethanol: 2 mg/ml. lambdamax: 329 nm. SMILES: NC(C(C=C1)=CC=C1C2=NC(C3=CC=C(OCO4)C4=C3)=C(C5=CC=CC=N5)N2)=O.O. InChi Code: InChI=1S/C22H16N4O3.H2O/c23-21(27)13-4-6-14(7-5-13)22-25-19(20(26-22)16-3-1-2-10-24-16)15-8-9-17-18(11-15)29-12-28-17,/h1-11H,12H2,(H2,23,27)(H,25,26),1H2. InChi Key: WQUIJVKNPYBZOF-UHFFFAOYSA-N.