Melanotan II (acetate)

Melanotan II is an agonist of melanocortin receptor 1 (MC1R), MC3R, MC4R, and MC5R (Kis = 0.67, 34, 6.6, and 46 nM, respectively, in COS cells expressing human recombinant receptors). It improves recovery of sciatic nerve function after mechanical injury in rats, and increases cisplatin-induced decreases in sensory nerve conduction velocity when administered at a dose of 20, but not 2 or 50, µg/kg. Melanotan II (1 nmol, i.c.v.) increases oxygen consumption and protein levels of uncoupling protein 1 (UCP1) in brown adipose tissue homogenates and decreases food intake, body weight, and serum levels of leptin, glucose, insulin, and cholesterol (Cay-9003100) in chow-fed and diet-induced obese rats.Formal Name: N-acetyl-L-norleucyl-L-alpha-aspartyl-L-histidyl-D-phenylalanyl-L-arginyl-L-tryptophyl-L-lysinamide, (2->7)-lactam, acetate. Synonyms: MT II. Molecular Formula: C50H69N15O9 . XC2H4O2. Formula Weight: 1024.2. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMF:PBS (pH 7.2) (1:4): 0.20 mg/ml, DMSO: 15 mg/ml, Ethanol: 1 mg/ml. SMILES: O=C(N[C@]([H])(C(N)=O)CCCCNC1=O)[C@H](CC2=CNC3=C2C=CC=C3)NC([C@H](CCCNC(N)=N)NC([C@](CC4=CC=CC=C4)([H])NC([C@H](CC5=CN=CN5)NC([C@@H](NC([C@@H](NC(C)=O)CCCC)=O)C1)=O)=O)=O)=O.CC(O)=O. InChi Code: InChI=1S/C50H69N15O9.C2H4O2/c1-3-4-16-36(59-29(2)66)44(69)65-41-25-42(67)55-20-11-10-18-35(43(51)68)60-47(72)39(23-31-26-57-34-17-9-8-15-33(31)34)63-45(70)37(19-12-21-56-50(52)53)61-46(71)38(22-30-13-6-5-7-14-30)62-48(73)40(64-49(41)74)24-32-27-54-28-58-32,1-2(3)4/h5-9,13-15,17,26-28,35-41,57H,3-4,10-12,16,18-25H2,1-2H3,(H2,51,68)(H,54,58)(H,55,67)(H,59,66)(H,60,72)(H,61,71)(H,62,73)(H,63,70)(H,64,74)(H,65,69)(H4,52,53,56),1H3,(H,3,4)/t35-,36-,37-,38+,39-,40-,41-,/m0./s1. InChi Key: GTAMEWQATOUMGW-GBRHMYBBSA-N.