Malonyl Coenzyme A (lithium salt)

Malonyl coenzyme A is a coenzyme A (CoA, Cay-16147) derivative that is used in fatty acid and polyketide synthesis and in the transport of alpha-ketoglutarate across the mitochondrial membrane. Malonyl-CoA is formed by acetyl-CoA carboxylase-mediated carboxylation of acetyl-CoA (Cay-16160). Fatty acid synthase catalyzes the NADPH-dependent condensation of malonyl-CoA and acetyl-CoA to produce palmitate. Proliferating human cancer cells upregulate this fatty acid synthesis pathway as a strategy for survival. High levels of malonyl-CoA, achieved through fatty acid synthase inhibition, have been proposed to contribute to cancer cell apoptosis. Manlonyl-CoA is exclusively used as the extender unit in the synthesis of bacterial aromatic polyketides.Formal Name: S-(hydrogen propanedioate) coenzyme A, lithium salt. CAS Number: 108347-84-8. Synonyms: Malonyl-CoA. Molecular Formula: C24H38N7O19P3S . XLi. Formula Weight: 860.5. Purity: >90%. Formulation: (Request formulation change), A crystalline solid. Solubility: PBS (pH 7.2): 10 mg/ml. lambdamax: 257 nm. SMILES: O[C@H]1[C@H](N2C=NC3=C2N=CN=C3N)O[C@H](COP(OP(OCC(C)(C)[C@@H](O)C(NCCC(NCCSC(CC(O)=O)=O)=O)=O)(O)=O)(O)=O)[C@H]1OP(O)(O)=O.[Li]. InChi Code: InChI=1S/C24H38N7O19P3S.Li/c1-24(2,19(37)22(38)27-4-3-13(32)26-5-6-54-15(35)7-14(33)34)9-47-53(44,45)50-52(42,43)46-8-12-18(49-51(39,40)41)17(36)23(48-12)31-11-30-16-20(25)28-10-29-21(16)31,/h10-12,17-19,23,36-37H,3-9H2,1-2H3,(H,26,32)(H,27,38)(H,33,. InChi Key: OPIJLICRFQMMJH-VYLCMXPPSA-N.